{"id":"W2101151590","doi":"10.3390/biology4010088","title":"PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins","year":2015,"lang":"en","type":"review","venue":"Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Dalhousie University; Oklahoma State University; U.S. Department of Agriculture; National Institutes of Health; National Science Foundation","keywords":"PDZ domain; Biology; Protein–protein interaction; Plasma protein binding; Cell biology; Protein domain; Computational biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009101487,0.0004025495,0.0004168403,0.0003034446,0.0001544333,0.0004691001,0.0003081785,0.0003623807,0.0009751029],"category_scores_gemma":[0.00008340309,0.0001417744,0.0001845465,0.0002909281,0.0001767057,0.0005533567,0.000230674,0.000769938,0.0008438729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004258943,"about_ca_system_score_gemma":0.0002411903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003977062,"about_ca_topic_score_gemma":0.0004809196,"domain_scores_codex":[0.9999686,0.000003323921,0.000002043875,0.000009940101,0.00001078398,0.000005336154],"domain_scores_gemma":[0.9999803,0.000004266477,0.000003735415,7.921221e-7,0.000006512765,0.00000432511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004544263,0.00009462114,0.0009351188,0.008799875,0.0001340133,0.002188336,0.0003355147,0.002268639,0.3852826,0.02335644,0.03358943,0.5425611],"study_design_scores_gemma":[0.00003247783,0.0002166177,0.002883156,0.0003013299,0.0001275326,0.004169066,0.0001312991,0.00205604,0.09795505,0.007323294,0.8847719,0.00003223711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02459828,0.9554082,0.006928907,0.002130476,0.0009058315,0.00004226074,0.0002710312,0.0001459557,0.009569122],"genre_scores_gemma":[0.07318252,0.9063345,0.005659927,0.002055288,0.0006970908,0.00005204764,0.0004730704,0.00002643065,0.01151909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0009751029,"threshold_uncertainty_score":0.003262043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07012299105399275,"score_gpt":0.3350527183707708,"score_spread":0.2649297273167781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}