{"id":"W2101155889","doi":"10.1159/000330086","title":"The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an <i>in Vitro</i> Model of Alzheimer Disease","year":2011,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada","keywords":"GSK-3; Neurotoxicity; Cholinergic; Acetylcholine; Intracellular; Glutamate receptor; Pharmacology; Gene isoform; Alzheimer's disease; Tau protein; In vitro; Biology; Antagonist; Kinase; Neuroscience; Chemistry; Cell biology; Biochemistry; Internal medicine; Receptor; Medicine; Toxicity; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008115718,0.0005615135,0.0005116481,0.0002450256,0.0001357439,0.0001654569,0.000336271,0.0003622111,0.001360524],"category_scores_gemma":[0.0001023486,0.0001329595,0.0001618645,0.000107002,0.0001679822,0.0002559454,0.0001939576,0.0007790238,0.0002719725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001862833,"about_ca_system_score_gemma":0.0002175967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199691,"about_ca_topic_score_gemma":0.002301738,"domain_scores_codex":[0.9999517,0.000008327165,0.000005222176,0.000009910024,0.00001050818,0.00001426513],"domain_scores_gemma":[0.9999305,0.000005699635,0.00002196826,0.000008137345,0.000008608218,0.00002512742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000636999,0.0001176042,0.00006277692,0.00006931021,0.0000121392,0.00004493885,0.0000121278,0.00003021933,0.9965759,0.00002485769,0.00006316933,0.002350037],"study_design_scores_gemma":[0.0001998725,0.007286453,0.00688033,0.00002758968,0.00008705228,0.0001925726,0.00006566422,0.0005564326,0.9818441,0.00008082554,0.002768631,0.00001037624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956276,0.001972696,0.0007225368,0.0001430119,0.00003876214,0.00003160712,0.0002070047,0.00009899882,0.001157724],"genre_scores_gemma":[0.9925421,0.002358176,0.001169466,0.0001274465,0.00002152192,0.0000425803,0.0004082118,0.0000212175,0.003309204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360524,"threshold_uncertainty_score":0.00455147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343773658619102,"score_gpt":0.2468217134588798,"score_spread":0.2233839768726887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}