{"id":"W2101155889","doi":"10.1159/000330086","title":"The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an <i>in Vitro</i> Model of Alzheimer Disease","year":2011,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada","keywords":"GSK-3; Neurotoxicity; Cholinergic; Acetylcholine; Intracellular; Glutamate receptor; Pharmacology; Gene isoform; Alzheimer's disease; Tau protein; In vitro; Biology; Antagonist; Kinase; Neuroscience; Chemistry; Cell biology; Biochemistry; Internal medicine; Receptor; Medicine; Toxicity; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009786213,0.0002222337,0.0003442557,0.00004991519,0.00007852186,0.00000655258,0.0001009539,0.0001213984,0.000006793302],"category_scores_gemma":[0.00005139488,0.0001608009,0.00006475398,0.00008258635,0.0006317486,0.00004976834,0.000091585,0.0001714678,6.838198e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005517146,"about_ca_system_score_gemma":0.00007528585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002888204,"about_ca_topic_score_gemma":0.000002503048,"domain_scores_codex":[0.9987954,0.00008832167,0.0003057533,0.000483666,0.00006718959,0.0002596092],"domain_scores_gemma":[0.9992371,0.00003852407,0.0000961483,0.000384029,0.0000540673,0.0001901637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001472636,0.0004288035,0.001746354,0.0001026787,0.00001596823,0.0001264903,0.0001013176,0.000006602184,0.995612,0.00004665592,0.0000155649,0.000324897],"study_design_scores_gemma":[0.001158549,0.0001158547,0.04979126,0.00002065262,0.0001128172,0.00001989604,0.00002025907,0.004038394,0.9443945,0.0001621219,0.00001329361,0.0001523862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927309,0.006837157,0.000002719558,0.00009438238,0.00004220766,0.0001687891,0.00005431947,0.00001232846,0.00005716052],"genre_scores_gemma":[0.9984801,0.00077596,0.00004515295,0.0002861502,0.0001012234,0.00002615067,0.0001878262,0.00001872272,0.00007872896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05121752,"threshold_uncertainty_score":0.6557271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343773658619102,"score_gpt":0.2468217134588798,"score_spread":0.2233839768726887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}