{"id":"W2101182375","doi":"10.2337/db15-0124","title":"Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Ghrelin; Glucose homeostasis; Endocrinology; Internal medicine; Homeostasis; Hepatocyte nuclear factors; Hepatocyte; Biology; Medicine; Hormone; Diabetes mellitus; Transcription factor; Insulin resistance; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870677,0.0006829597,0.0004980994,0.0007511739,0.0002540794,0.0002606095,0.0004070493,0.0005349179,0.001511876],"category_scores_gemma":[0.0001635848,0.0002983055,0.0004776496,0.0001966868,0.0005960586,0.0002956418,0.0003038172,0.001328957,0.0004167995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000535088,"about_ca_system_score_gemma":0.0004379472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156854,"about_ca_topic_score_gemma":0.00201577,"domain_scores_codex":[0.9998509,0.00001493639,0.00001677962,0.0000340232,0.00003765501,0.00004572453],"domain_scores_gemma":[0.999777,0.0000189595,0.00007901798,0.00001673793,0.00001354891,0.00009472966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008952726,0.0001354796,0.0002161405,0.00003830795,0.00001308968,0.0001412175,0.000028878,0.00008987311,0.9961758,0.000183585,0.0001055492,0.00197681],"study_design_scores_gemma":[0.0007393855,0.002910324,0.02198315,0.00004844869,0.00009018476,0.0008194812,0.0001752913,0.002927483,0.9636719,0.0007095719,0.005888232,0.00003651265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950362,0.0006579669,0.001921513,0.000262654,0.00009704337,0.00003304963,0.0007352544,0.0003156713,0.0009406156],"genre_scores_gemma":[0.9860426,0.001458438,0.005417111,0.0002593593,0.0000529235,0.0001384404,0.001338662,0.0002633931,0.005029181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511876,"threshold_uncertainty_score":0.005057693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04131429906264156,"score_gpt":0.2548141087428222,"score_spread":0.2134998096801807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}