{"id":"W2101187809","doi":"10.1074/jbc.m412966200","title":"Regulation of Phospholipase C-δ1 through Direct Interactions with the Small GTPase Ral and Calmodulin","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; University of Manitoba; Manitoba Health Research Council; Heart and Stroke Foundation of Canada","keywords":"Calmodulin; GTPase; Small GTPase; Cell biology; Chemistry; Phospholipase; Biophysics; Biology; Signal transduction; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031698,0.0001089603,0.0001623969,0.000009605701,0.00005847057,0.00001337205,0.0001064459,0.0001056456,0.00006501855],"category_scores_gemma":[0.00009880719,0.00006035554,0.00009157365,0.00005980895,0.0002001817,0.000008288388,0.00004282889,0.0001444414,4.525066e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001369323,"about_ca_system_score_gemma":0.00003872665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003433742,"about_ca_topic_score_gemma":0.000003219072,"domain_scores_codex":[0.9993513,0.00004228746,0.000274555,0.000132694,0.0000918002,0.0001073481],"domain_scores_gemma":[0.999303,0.00002939039,0.0003216643,0.0001340189,0.0001521884,0.00005976449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003741468,0.00007014041,0.0004493439,0.00001376801,0.00004498188,0.000003461705,0.00003345839,0.0004082423,0.9958788,0.00002288043,0.0002966732,0.00240411],"study_design_scores_gemma":[0.0005469552,0.0001785801,0.001995404,0.00004014868,0.00002543255,0.0001985185,0.00008207963,0.00008333921,0.9741606,0.00007095998,0.02252564,0.0000923562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956079,0.001462416,0.001136885,0.000905035,0.00002318426,0.00006244956,0.000008238858,0.000003655243,0.0007902287],"genre_scores_gemma":[0.9970599,0.0001373119,0.002085026,0.0001360473,0.0002859514,0.000003064603,0.00001605144,0.000006030945,0.0002706631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02222897,"threshold_uncertainty_score":0.2461227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902169705801398,"score_gpt":0.2505989970007099,"score_spread":0.2315772999426959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}