{"id":"W2101187809","doi":"10.1074/jbc.m412966200","title":"Regulation of Phospholipase C-δ1 through Direct Interactions with the Small GTPase Ral and Calmodulin","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; University of Manitoba; Manitoba Health Research Council; Heart and Stroke Foundation of Canada","keywords":"Calmodulin; GTPase; Small GTPase; Cell biology; Chemistry; Phospholipase; Biophysics; Biology; Signal transduction; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256968,0.0002566448,0.0001647895,0.0001580326,0.0001465372,0.0003089758,0.0002627534,0.0001592063,0.0007148791],"category_scores_gemma":[0.0001726935,0.0001151951,0.0001289381,0.00007945836,0.0002933197,0.0001498,0.0002778484,0.0003784488,0.0002080632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000479173,"about_ca_system_score_gemma":0.0001761964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005710135,"about_ca_topic_score_gemma":0.0009628733,"domain_scores_codex":[0.9998823,0.00001918738,0.000006480172,0.00002659639,0.00003469534,0.00003076749],"domain_scores_gemma":[0.9999295,0.00001587256,0.00002310969,0.000006471257,0.00000740581,0.00001754856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000838999,0.000009060551,0.0002352396,0.00003754548,0.000002964324,0.0000626113,0.0000119212,0.00005838124,0.9974239,0.0003346386,0.00003118519,0.001708644],"study_design_scores_gemma":[0.00004644461,0.00008926345,0.008398771,0.00001085953,0.00001380889,0.000398721,0.00004292513,0.001697947,0.9850149,0.0002102752,0.004071289,0.000004797386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854918,0.007249867,0.00425662,0.0002602622,0.00003349664,0.00003462325,0.0001483637,0.00008321083,0.002441674],"genre_scores_gemma":[0.9948959,0.001626052,0.001649812,0.00004489845,0.00001012106,0.00002211203,0.0001026099,0.000008013229,0.001640519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007148791,"threshold_uncertainty_score":0.003476679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902169705801398,"score_gpt":0.2505989970007099,"score_spread":0.2315772999426959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}