{"id":"W2101205238","doi":"10.1371/journal.pone.0062721","title":"A New Class of Small Molecule Inhibitor of BMP Signaling","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Ministero dello Sviluppo Economico; Cancer Research UK; University of Oxford; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; GlaxoSmithKline; Eli Lilly and Company; Fondation Leducq; National Heart, Lung, and Blood Institute; Pfizer; Diamond Light Source; National Institutes of Health; Harvard NeuroDiscovery Center","keywords":"Bone morphogenetic protein; Fibrodysplasia ossificans progressiva; BMPR2; Zebrafish; Signal transduction; Kinase; Small molecule; Drug discovery; Pharmacology; Cell biology; Chemistry; Phosphorylation; Chemical genetics; Bone morphogenetic protein 2; Biochemistry; Biology; In vitro; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002695059,0.00004548455,0.0001606954,0.00006153335,0.00001208329,0.000002969274,0.00003721578,0.00006760842,0.001196213],"category_scores_gemma":[0.00004874344,0.00003847877,0.00004395381,0.00009285489,0.00002746603,0.00002164427,0.000009491631,0.0000924068,0.00009510617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009679284,"about_ca_system_score_gemma":0.00006252796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005009069,"about_ca_topic_score_gemma":8.71867e-7,"domain_scores_codex":[0.999491,0.00001301593,0.0002174813,0.00007656169,0.0001278934,0.00007399426],"domain_scores_gemma":[0.9995325,0.00002306572,0.00007223327,0.0001587003,0.0001245648,0.00008897173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006313883,0.0004939046,0.001118215,0.0001280633,0.0001399094,9.862105e-7,0.0001937211,8.131053e-7,0.9967625,0.0003346165,0.0003097391,0.0005112552],"study_design_scores_gemma":[0.0007736188,0.0001598597,0.002940651,0.0004484332,0.0001454426,0.000001334741,0.00006907548,0.0003779045,0.994788,0.0001505473,0.00009718158,0.00004796048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909015,0.00007111498,0.0004673536,0.001639421,0.00001578152,0.0003767869,0.000002586398,0.00002346445,0.00650197],"genre_scores_gemma":[0.9898682,0.00001068568,0.005933614,0.0001413096,0.00006221417,0.00002038594,0.00001052598,0.000007572858,0.003945485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00546626,"threshold_uncertainty_score":0.9997168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05132590732170855,"score_gpt":0.2422106833740612,"score_spread":0.1908847760523526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}