{"id":"W2101205238","doi":"10.1371/journal.pone.0062721","title":"A New Class of Small Molecule Inhibitor of BMP Signaling","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Ministero dello Sviluppo Economico; Cancer Research UK; University of Oxford; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; GlaxoSmithKline; Eli Lilly and Company; Fondation Leducq; National Heart, Lung, and Blood Institute; Pfizer; Diamond Light Source; National Institutes of Health; Harvard NeuroDiscovery Center","keywords":"Bone morphogenetic protein; Fibrodysplasia ossificans progressiva; BMPR2; Zebrafish; Signal transduction; Kinase; Small molecule; Drug discovery; Pharmacology; Cell biology; Chemistry; Phosphorylation; Chemical genetics; Bone morphogenetic protein 2; Biochemistry; Biology; In vitro; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009851272,0.0004780397,0.000281854,0.0003499445,0.0001291878,0.0001994861,0.000282207,0.0002381161,0.002372164],"category_scores_gemma":[0.00008846838,0.0001156949,0.0002576829,0.0002007437,0.0001589745,0.000188256,0.0002192986,0.0006251441,0.001080784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368506,"about_ca_system_score_gemma":0.0002356848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004292062,"about_ca_topic_score_gemma":0.001255176,"domain_scores_codex":[0.9999318,0.000007459798,0.000004447564,0.00002087405,0.00002418672,0.00001121218],"domain_scores_gemma":[0.9999739,0.000004351063,0.000005948673,0.000002571212,0.000004452975,0.000008802558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003873469,0.0001626319,0.0003669627,0.0002822048,0.00003015635,0.0003517232,0.0000342527,0.0005811442,0.9298348,0.001312847,0.001358482,0.06529755],"study_design_scores_gemma":[0.0009107548,0.004647661,0.005980212,0.00005989986,0.0001039748,0.004171565,0.00004181931,0.002296807,0.8730471,0.0005082433,0.108169,0.00006301107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8296581,0.0615025,0.04868287,0.001018416,0.0004839885,0.00115239,0.003919255,0.001399747,0.05218272],"genre_scores_gemma":[0.9116495,0.02791685,0.0266424,0.000775107,0.00008091729,0.0005458692,0.00336386,0.00005783146,0.02896767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372164,"threshold_uncertainty_score":0.007935703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05132590732170855,"score_gpt":0.2422106833740612,"score_spread":0.1908847760523526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}