{"id":"W2101205453","doi":"10.1096/fj.06-7457com","title":"The Toll‐like receptor 7/8‐ligand resiquimod (R‐848) primes human neutrophils for leukotriene B <sub>4</sub> , prostaglandin E <sub>2</sub> and platelet‐activating factor biosynthesis","year":2007,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung","keywords":"TLR7; Arachidonic acid; Lipid signaling; Platelet-activating factor; Toll-like receptor; Phospholipase A2; Innate immune system; Chemistry; Cell biology; Platelet activation; Leukotriene B4; Biology; Receptor; Biochemistry; Platelet; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002403138,0.0003525144,0.000393883,0.0002081236,0.003097869,0.0002091154,0.0003913541,0.0003342063,0.00002001491],"category_scores_gemma":[0.0003908096,0.0002118522,0.0002039499,0.0001736153,0.0003963631,0.000313102,0.0001067154,0.000780663,0.0000426474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001423975,"about_ca_system_score_gemma":0.0001478562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007870006,"about_ca_topic_score_gemma":0.00001745234,"domain_scores_codex":[0.9974945,0.0004549531,0.0007823659,0.0003028132,0.0001248573,0.0008405728],"domain_scores_gemma":[0.9971513,0.001606824,0.0006304806,0.0003625336,0.0001789597,0.00006992207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002202818,0.00004036321,0.000146111,0.00001661725,0.0002664831,0.000007506834,0.0009401438,0.000002364561,0.9319619,0.0001934974,0.001092215,0.06312999],"study_design_scores_gemma":[0.001807215,0.0004427366,0.003447035,0.0001039237,0.00004305163,0.0004321316,0.0008104389,0.000004031947,0.9834711,0.0002889278,0.008868122,0.0002812625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944977,0.002619177,0.0004783105,0.0008143934,0.0006705172,0.0007549481,0.00003116262,0.00005795922,0.00007579441],"genre_scores_gemma":[0.9981084,0.001094396,0.00003918963,0.0001088945,0.0003182182,0.0000260014,0.00003519495,0.00004893773,0.0002207985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06284872,"threshold_uncertainty_score":0.9981999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368390361365298,"score_gpt":0.2363711230144756,"score_spread":0.2226872194008226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}