{"id":"W2101205453","doi":"10.1096/fj.06-7457com","title":"The Toll‐like receptor 7/8‐ligand resiquimod (R‐848) primes human neutrophils for leukotriene B <sub>4</sub> , prostaglandin E <sub>2</sub> and platelet‐activating factor biosynthesis","year":2007,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung","keywords":"TLR7; Arachidonic acid; Lipid signaling; Platelet-activating factor; Toll-like receptor; Phospholipase A2; Innate immune system; Chemistry; Cell biology; Platelet activation; Leukotriene B4; Biology; Receptor; Biochemistry; Platelet; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022065,0.0004298683,0.0002661009,0.0001017708,0.0001066386,0.0001559666,0.0001315008,0.0002700144,0.001310324],"category_scores_gemma":[0.0001166695,0.0001233829,0.0002141932,0.00006223111,0.0001383531,0.0001535516,0.0001414014,0.0003041348,0.0007620793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811737,"about_ca_system_score_gemma":0.0001326333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427563,"about_ca_topic_score_gemma":0.0001636565,"domain_scores_codex":[0.9998721,0.00003819522,0.00001122776,0.00002250578,0.00002272406,0.00003323874],"domain_scores_gemma":[0.9999518,0.00001417384,0.00001384854,0.000008426924,0.000004982342,0.000006750307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003418968,0.00006161303,0.0002015989,0.00004762063,0.000005378288,0.00008866186,0.00001280293,0.0001070852,0.9962687,0.00004929714,0.00009506253,0.002720153],"study_design_scores_gemma":[0.00007391114,0.001745823,0.003965997,0.000008333279,0.00002060136,0.0006823132,0.00002248295,0.000906729,0.9893567,0.00005754806,0.003153124,0.00000629192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939595,0.002303608,0.001928132,0.0001079606,0.00005484643,0.00007173894,0.0002188917,0.00007752362,0.001277798],"genre_scores_gemma":[0.9951788,0.0007659634,0.002182554,0.00007225717,0.00003700258,0.00007030467,0.0004631271,0.000009856602,0.001220209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310324,"threshold_uncertainty_score":0.004383445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368390361365298,"score_gpt":0.2363711230144756,"score_spread":0.2226872194008226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}