{"id":"W2101214496","doi":"10.1038/mp.2011.89","title":"Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms","year":2011,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Institutes of Health; Wellcome Trust","keywords":"Pedigree chart; Genetics; Schizoaffective disorder; Bipolar disorder; Genetic linkage; Microsatellite; Biology; Linkage (software); Linkage disequilibrium; Genotyping; Single-nucleotide polymorphism; Genotype; Psychology; Psychosis; Allele; Psychiatry; Mood; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003247655,0.0002459695,0.0004406666,0.0003015021,0.00009036595,0.000009435615,0.0003348862,0.0002489694,0.00009831026],"category_scores_gemma":[0.00009929051,0.0002570295,0.0005003964,0.0005735839,0.000124261,0.000003997628,0.0001380043,0.0001137692,0.000008165273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002013884,"about_ca_system_score_gemma":0.0001049309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893523,"about_ca_topic_score_gemma":0.0001409928,"domain_scores_codex":[0.9982112,0.0001823841,0.0005471488,0.0004959857,0.000158565,0.0004047083],"domain_scores_gemma":[0.9986671,0.00001383433,0.000363779,0.00070971,0.0001180794,0.000127477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002464211,0.0001925973,0.5700977,0.0000112865,0.001343472,0.000004301334,0.00007980874,0.000519002,0.427398,0.00008062956,0.00007461962,0.0001739611],"study_design_scores_gemma":[0.0005402055,0.0004568387,0.9583516,0.0000146164,0.002044896,0.00001155918,0.0001870423,0.0005706194,0.03403173,0.0005548166,0.002651853,0.0005842973],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631678,0.005586065,0.02947709,0.00009924439,0.0003740962,0.00013515,0.00004449973,0.0000162517,0.001099812],"genre_scores_gemma":[0.9689373,0.0001115968,0.02992745,0.0005832753,0.000136739,0.00000626656,0.0001649883,0.00004184756,0.00009049795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3933663,"threshold_uncertainty_score":0.9999882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061014382505314,"score_gpt":0.2454425653160584,"score_spread":0.2248324214910052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}