{"id":"W2101235030","doi":"10.1111/cen3.12079","title":"Mechanisms of action of fingolimod in multiple sclerosis","year":2014,"lang":"en","type":"article","venue":"Clinical and Experimental Neuroimmunology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Fingolimod; Multiple sclerosis; Neuroscience; Immune system; Medicine; Sphingosine-1-phosphate; Sphingosine; Receptor; Pharmacology; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003551211,0.0006190024,0.0003930074,0.0005556441,0.0002351596,0.0006563544,0.0003445443,0.0006759598,0.0021716],"category_scores_gemma":[0.0001098388,0.0001554117,0.0004521042,0.0001821544,0.0003451109,0.0003620157,0.0003783107,0.0006872307,0.000522144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005899548,"about_ca_system_score_gemma":0.0002688535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000328672,"about_ca_topic_score_gemma":0.0002563012,"domain_scores_codex":[0.9998865,0.00002813394,0.000008193551,0.0000194424,0.00003597339,0.0000216863],"domain_scores_gemma":[0.9999565,0.00000811485,0.00001649578,0.000002917217,0.000008037399,0.000008021748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001417138,0.0003929587,0.001096579,0.003039764,0.0002310055,0.003912253,0.0002634736,0.002504573,0.6980971,0.04216601,0.004655112,0.242224],"study_design_scores_gemma":[0.0006686765,0.004608871,0.01866287,0.0008402228,0.0005463231,0.01442014,0.0003507527,0.003982154,0.5459226,0.04010982,0.36979,0.00009749093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.203135,0.7328161,0.01794414,0.006629349,0.001026382,0.0003023825,0.0007229695,0.0003582138,0.03706557],"genre_scores_gemma":[0.6605229,0.318598,0.00494269,0.001247331,0.0008122186,0.0002252624,0.0003697377,0.00001512962,0.01326672],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0021716,"threshold_uncertainty_score":0.007264733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07372560110444362,"score_gpt":0.3157654904586104,"score_spread":0.2420398893541667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}