{"id":"W2101265600","doi":"10.1200/jco.2013.54.8404","title":"Systemic Therapy in Men With Metastatic Castration-Resistant Prostate Cancer: American Society of Clinical Oncology and Cancer Care Ontario Clinical Practice Guideline","year":2014,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Genentech; Astellas Pharma; Bayer HealthCare; Sanofi; Exelixis; AstraZeneca; American Society of Clinical Oncology; GlaxoSmithKline; Cancer Care Ontario; Amgen; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Cabazitaxel; Docetaxel; Enzalutamide; Prostate cancer; Internal medicine; Oncology; Abiraterone acetate; Prednisone; Mitoxantrone; Androgen deprivation therapy; Cancer; Chemotherapy; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.01917472,0.0006424025,0.01514247,0.0002494898,0.00007187665,0.000024427,0.0004186489,0.001102054,0.00008581605],"category_scores_gemma":[0.003240567,0.000358209,0.002123762,0.0005051367,0.001785612,0.0001847037,0.0001268322,0.005331446,0.000003209942],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002299147,"about_ca_system_score_gemma":0.06945899,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01540932,"about_ca_topic_score_gemma":0.02718176,"domain_scores_codex":[0.976689,0.005819888,0.01495259,0.0008613724,0.001050951,0.0006262222],"domain_scores_gemma":[0.9642786,0.01410472,0.01716841,0.0005203353,0.003038025,0.0008899088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01881503,0.002152656,0.02328156,0.004008163,0.006320192,0.001080372,0.0006323889,0.000009378834,7.824501e-7,0.000006012369,0.007187504,0.936506],"study_design_scores_gemma":[0.0211535,0.04989298,0.004678329,0.008966575,0.006515374,0.0006839507,0.001578565,0.00002330557,3.852084e-7,0.000007048652,0.9062082,0.0002918142],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01110313,0.9786163,0.00001771468,0.00565887,0.001001467,0.002675119,0.0000868462,0.00001059286,0.0008299642],"genre_scores_gemma":[0.001280901,0.9825763,0.01184198,0.001604973,0.001791108,0.0001898153,0.0000557417,0.0000831181,0.0005761013],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9362141,"threshold_uncertainty_score":0.999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3033643931063716,"score_gpt":0.6127817755872027,"score_spread":0.3094173824808311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}