{"id":"W2101266783","doi":"10.1186/1742-4690-10-160","title":"Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gammaas an intrinsic negative regulator of viral replication","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; GIS-Institut des Maladies Rares; Université de Montréal; Fondation de France; Institut National de la Santé et de la Recherche Médicale; Fondation du CHUM; Canadian Foundation for AIDS Research; McGill University; Styrelsen för Internationellt Utvecklingssamarbete; Pfizer","keywords":"Biology; Viral replication; Molecular biology; Nuclear receptor; Cell biology; C-C chemokine receptor type 6; Receptor; Chemokine receptor; Gene; Cell culture; Transcription factor; Genetics; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343101,0.0002001153,0.0002798249,0.0005532219,0.0002380518,0.0005080742,0.00009818091,0.0002094846,0.001827585],"category_scores_gemma":[0.0001507175,0.0001157831,0.0002994624,0.000589192,0.000227483,0.0001170963,0.0001657691,0.0004208738,0.0004371804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885152,"about_ca_system_score_gemma":0.0002007115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003606162,"about_ca_topic_score_gemma":0.0006935658,"domain_scores_codex":[0.9998333,0.00001174078,0.000006867084,0.00005089179,0.0000378199,0.00005929756],"domain_scores_gemma":[0.9998059,0.00004018209,0.00007164319,0.00001490672,0.00003090989,0.00003651392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005273584,0.00003254895,0.02212736,0.000113821,0.00002275497,0.0001354795,0.0000972498,0.00008426083,0.9733184,0.00005824805,0.0001028406,0.003379614],"study_design_scores_gemma":[0.00003101724,0.0007131361,0.6394917,0.00006420557,0.0001668964,0.001384482,0.0007381859,0.001282618,0.3524865,0.0002702246,0.003352376,0.00001880258],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956688,0.001038579,0.0006718193,0.00004959636,0.000008509046,0.00001548895,0.002008446,0.00002637816,0.0005122243],"genre_scores_gemma":[0.990444,0.001337773,0.001850251,0.00009447709,0.00002493543,0.00006457861,0.004855927,0.00002066952,0.001307383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827585,"threshold_uncertainty_score":0.006113946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008888047847236142,"score_gpt":0.2359301649523633,"score_spread":0.2270421171051271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}