{"id":"W2101292434","doi":"10.1093/carcin/bgq221","title":"Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Cancer research; DNA methyltransferase; DNMT1; Biology; Metastasis; Neoplastic transformation; Carcinogenesis; Methyltransferase; Gene silencing; Cancer; DNA demethylation; Cancer cell; Tumor suppressor gene; Methylation; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342395,0.0001985359,0.0001806334,0.00004624287,0.00008399515,0.00001588621,0.00008987686,0.0002343953,0.00002882669],"category_scores_gemma":[0.000009280108,0.0001887465,0.00008794882,0.0001027192,0.00005490867,0.00001495896,0.0000294757,0.00008924337,0.000001720827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005454433,"about_ca_system_score_gemma":0.00008974898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008325217,"about_ca_topic_score_gemma":0.0006226039,"domain_scores_codex":[0.9989278,0.00006370619,0.0002391759,0.0003607242,0.0001718584,0.0002367928],"domain_scores_gemma":[0.9993465,0.00002601974,0.0001305979,0.0001937274,0.0001849846,0.0001181491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054145,0.00007413475,0.01228262,0.0001378891,0.00001538313,5.669732e-7,0.0002671691,0.0001090134,0.9778461,0.000009478962,0.00007113514,0.009081116],"study_design_scores_gemma":[0.0006230594,0.0001589029,0.1159168,0.00001669143,0.00005031674,0.000001087515,0.00004942621,0.00003726214,0.8821239,0.00001466762,0.0008202035,0.0001876909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888054,0.009487021,0.00045136,0.00007035547,0.0003935942,0.0003773267,0.00009126993,0.00000939647,0.0003143487],"genre_scores_gemma":[0.9871939,0.01202688,0.0001705613,0.00005734353,0.0003346399,0.00008056909,0.00006596708,0.00003254276,0.00003755861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1036342,"threshold_uncertainty_score":0.7696859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006989973652087983,"score_gpt":0.2199345231464249,"score_spread":0.2129445494943369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}