{"id":"W2101292434","doi":"10.1093/carcin/bgq221","title":"Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Cancer research; DNA methyltransferase; DNMT1; Biology; Metastasis; Neoplastic transformation; Carcinogenesis; Methyltransferase; Gene silencing; Cancer; DNA demethylation; Cancer cell; Tumor suppressor gene; Methylation; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247546,0.0003189304,0.0002700949,0.0001406922,0.0001086713,0.000148873,0.0001560804,0.0001784387,0.00141283],"category_scores_gemma":[0.0001028808,0.0001292853,0.0001838652,0.0001395961,0.0001368954,0.0001037221,0.0001087683,0.0004511906,0.0002785505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035985,"about_ca_system_score_gemma":0.0002807337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233586,"about_ca_topic_score_gemma":0.002401755,"domain_scores_codex":[0.9998958,0.00001873259,0.00001112578,0.00002586358,0.00002696809,0.00002150153],"domain_scores_gemma":[0.9999411,0.00001874431,0.000009891789,0.000008557512,0.000009498744,0.00001212386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075603,0.00004232047,0.00006717911,0.00003984575,0.000005993018,0.00001677801,0.00001136074,0.00007768707,0.9979977,0.00006663083,0.00006222474,0.001504828],"study_design_scores_gemma":[0.00001172408,0.000231225,0.0006229181,0.000001547225,0.00001114679,0.00004266301,0.000005075419,0.0005153074,0.9972549,0.00001079874,0.001290984,0.000001608071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895958,0.003578281,0.002216477,0.0001493622,0.0000517815,0.00006507913,0.0005801889,0.0001320729,0.003630806],"genre_scores_gemma":[0.9899676,0.002457566,0.00275971,0.00006097657,0.00000820936,0.00006769726,0.0007462229,0.0000251135,0.003906803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141283,"threshold_uncertainty_score":0.00472641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006989973652087983,"score_gpt":0.2199345231464249,"score_spread":0.2129445494943369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}