{"id":"W2101316199","doi":"10.1093/jb/mvg005","title":"Development and Characterization of a Novel Fusion Protein Composed of a Human IgG1 Heavy Chain Constant Region and a Single-Chain Fragment Variable Antibody against Venezuelan Equine Encephalitis Virus","year":2003,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Defence Research and Development Canada","funders":"","keywords":"Antibody; Recombinant DNA; Molecular biology; Epitope; Virology; Monoclonal antibody; Fusion protein; Biology; Immunogenicity; Immunoglobulin light chain; Antigen; Chemistry; Gene; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000511696,0.0001328928,0.0003605959,0.00004986491,0.0000708122,0.00001010523,0.00006501575,0.00006822678,0.00001175274],"category_scores_gemma":[0.00006178214,0.0000965431,0.00004206926,0.00009691384,0.0001181892,0.00003110394,0.00003128184,0.0001135698,3.40234e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004928258,"about_ca_system_score_gemma":0.0001689754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001167291,"about_ca_topic_score_gemma":5.36563e-7,"domain_scores_codex":[0.9988627,0.00005189841,0.0005672874,0.0001144498,0.0002632434,0.0001404353],"domain_scores_gemma":[0.9988725,0.00002555517,0.0006517764,0.0001561481,0.0001757399,0.000118305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007441335,0.0005288027,0.0004275129,0.0004226199,0.00008685466,0.000018772,0.0004405956,0.000001303333,0.996116,0.0001175355,0.000002858416,0.001092975],"study_design_scores_gemma":[0.003531106,0.0005537157,0.001165036,0.001802101,0.0001195234,0.0002209498,0.0004797132,0.0001421584,0.991743,0.00001903576,0.000124261,0.00009942604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967432,0.0008648649,0.001792623,0.0001410338,0.00002033923,0.0002986549,0.00002349951,0.000003830147,0.0001119516],"genre_scores_gemma":[0.9989457,0.0001193537,0.0007225696,0.0000813592,0.00004090857,0.000003288093,0.00003010986,0.00001050131,0.00004626285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004373062,"threshold_uncertainty_score":0.3936913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690318527624768,"score_gpt":0.2490398349958372,"score_spread":0.2321366497195896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}