{"id":"W2101346799","doi":"10.1124/jpet.103.054304","title":"Functional Expression of the Multidrug Resistance Protein 1 in Microglia","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"American Association of Pharmaceutical Scientists","keywords":"Microglia; Biology; Choroid plexus; Cell biology; Efflux; Probenecid; Intracellular; Molecular biology; Pharmacology; Biochemistry; Immunology; Central nervous system; Inflammation; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075569,0.00008264383,0.0001910792,0.00005168802,0.00004774058,0.000002111476,0.00005300863,0.00006375624,0.0001317349],"category_scores_gemma":[0.000002433189,0.00005043138,0.00007730732,0.00007674123,0.000121858,0.00004543271,0.000007512582,0.0002244737,3.904561e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004099153,"about_ca_system_score_gemma":0.00008715476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.78547e-7,"about_ca_topic_score_gemma":0.000001133353,"domain_scores_codex":[0.9992941,0.00008209026,0.0003001495,0.00007165669,0.0001467045,0.0001052854],"domain_scores_gemma":[0.9996704,0.00001832554,0.000179923,0.0000494114,0.00004711542,0.00003482605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001353669,0.0004070492,0.001544923,0.00002775825,0.00004277088,0.00002012946,0.0005220072,0.000003947862,0.9956385,0.0002142623,0.000186444,0.0000385047],"study_design_scores_gemma":[0.003386004,0.0001186634,0.002069342,0.0001035758,0.0000492714,0.0000521939,0.0006057605,0.000003699728,0.9869674,0.0001738563,0.006423071,0.000047138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930115,0.005488978,0.00005243071,0.0005245174,0.0004531528,0.0001856255,0.000001380233,0.000002034094,0.0002803231],"genre_scores_gemma":[0.997238,0.0001058291,0.001265846,0.0005110946,0.00004643529,0.000004548405,2.960448e-7,0.000007574738,0.0008203162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00867111,"threshold_uncertainty_score":0.2056532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044690547565155,"score_gpt":0.3014719878440731,"score_spread":0.2810250823684216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}