{"id":"W2101372260","doi":"10.2337/db14-0332","title":"β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust; National Institute for Health and Care Research; Juvenile Diabetes Research Foundation United States of America","keywords":"CD8; T cell; Immunology; Biology; Cytotoxic T cell; Antigen; Cell; Flow cytometry; Type 1 diabetes; Immune system; Diabetes mellitus; Endocrinology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002854012,0.000286901,0.0003061466,0.00008785881,0.00008658284,0.00006199261,0.0003299353,0.0002718513,0.00009892425],"category_scores_gemma":[0.0001030586,0.0002887297,0.0001157955,0.0002867624,0.00007129565,0.000009601755,0.0001164707,0.0001729778,0.0001547693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003608073,"about_ca_system_score_gemma":0.00009814429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005568137,"about_ca_topic_score_gemma":0.000009950989,"domain_scores_codex":[0.9981263,0.000123493,0.0002842658,0.0005358346,0.0001622106,0.0007679551],"domain_scores_gemma":[0.9991539,0.00004212377,0.0001233409,0.0004632277,0.00007802629,0.0001394335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007744861,0.0001863835,0.1109697,0.00007930055,0.00003596213,4.648529e-7,0.00004452617,0.0001894282,0.8695082,0.00004828607,0.01461298,0.004317045],"study_design_scores_gemma":[0.002188152,0.001256605,0.0238855,0.00006512645,0.00003672264,3.784623e-8,0.00008040592,0.000569707,0.78354,0.0004209444,0.1870417,0.0009151783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668,0.02449697,0.000007570596,0.0001076739,0.0003679054,0.0001766419,0.00001227602,0.00004174936,0.007989153],"genre_scores_gemma":[0.9973848,0.0006844617,0.0001294669,0.0005101718,0.0003032682,0.00002668113,0.000259279,0.00006252186,0.0006393091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1724287,"threshold_uncertainty_score":0.9999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005191010980544128,"score_gpt":0.2045683318667785,"score_spread":0.1993773208862344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}