{"id":"W2101393342","doi":"10.1124/dmd.109.029959","title":"Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR− and Wistar Rat Liver Preparations","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Multidrug resistance-associated protein 2; Sulfation; Metabolite; Excretion; Transporter; Glucuronidation; Sulfotransferase; Chemistry; Estrogen; Metabolism; Microsome; P-glycoprotein; Glucuronide; Enzyme; Internal medicine; Biochemistry; Endocrinology; Biology; ATP-binding cassette transporter; Multiple drug resistance; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004964136,0.0002252248,0.0006272439,0.0003599779,0.00006586281,0.00001063945,0.00004483843,0.0001471254,0.000004821484],"category_scores_gemma":[0.00007562089,0.0002032864,0.00004868863,0.0002887739,0.0002024709,0.0003601318,0.00000962598,0.0002286843,7.478235e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001270487,"about_ca_system_score_gemma":0.00004943935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001911419,"about_ca_topic_score_gemma":0.001120028,"domain_scores_codex":[0.9983977,0.0001057507,0.0007083553,0.0003567883,0.0002391215,0.0001923037],"domain_scores_gemma":[0.9992243,0.00006344829,0.0003313773,0.0001436049,0.0001228851,0.0001143926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002416003,0.000648059,0.004235669,0.000473551,0.00003601836,0.00001016228,0.008274685,0.00003833255,0.9810332,0.002250718,0.000001347673,0.0005822673],"study_design_scores_gemma":[0.01022015,0.0002513159,0.4914204,0.0009126273,0.0003156947,0.000002740493,0.0005784435,0.003087638,0.4927453,0.0001900271,0.00003883097,0.00023692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958124,0.002609423,0.00004658576,0.0001183504,0.00005144356,0.001037448,0.0002826578,0.00001623229,0.00002547797],"genre_scores_gemma":[0.9979709,0.001223239,0.0002679776,0.00001656471,0.00001609891,0.00005083753,0.000383716,0.00001686951,0.00005374328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4882879,"threshold_uncertainty_score":0.8289781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005336374852177865,"score_gpt":0.2448613152844827,"score_spread":0.2395249404323048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}