{"id":"W2101393342","doi":"10.1124/dmd.109.029959","title":"Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-Associated Protein 2-Mediated Excretion of Estradiol 17β-d-Glucuronide and Its 3-Sulfate Metabolite on Net Sulfation in Perfused TR− and Wistar Rat Liver Preparations","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Multidrug resistance-associated protein 2; Sulfation; Metabolite; Excretion; Transporter; Glucuronidation; Sulfotransferase; Chemistry; Estrogen; Metabolism; Microsome; P-glycoprotein; Glucuronide; Enzyme; Internal medicine; Biochemistry; Endocrinology; Biology; ATP-binding cassette transporter; Multiple drug resistance; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005011291,0.0004008403,0.0005388593,0.0002318659,0.0001864765,0.0005827898,0.0002641472,0.0003010331,0.001646438],"category_scores_gemma":[0.0003558879,0.0003131551,0.0003349223,0.0001971579,0.0005777954,0.0009581042,0.0002260437,0.000364155,0.0002937359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003709088,"about_ca_system_score_gemma":0.000300801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009777062,"about_ca_topic_score_gemma":0.001036784,"domain_scores_codex":[0.9998031,0.0000719306,0.00001418471,0.00003742652,0.00002144982,0.00005195285],"domain_scores_gemma":[0.9997414,0.00007645744,0.00003887196,0.00004424941,0.000030065,0.00006907157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0110174,0.0000693851,0.00139553,0.00005142654,0.00003066739,0.0001397828,0.0001065236,0.0001874997,0.9837613,0.0004360443,0.00005455471,0.002749942],"study_design_scores_gemma":[0.0001688168,0.001121168,0.01276332,0.000006242109,0.00006731012,0.0001973115,0.0001325657,0.003419006,0.9810291,0.0002176259,0.0008602912,0.00001715592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982626,0.0005529367,0.000594919,0.00005365588,0.000009330958,0.000007166756,0.00008824753,0.00002835237,0.0004028415],"genre_scores_gemma":[0.9979064,0.0002796472,0.0006771417,0.00002366233,0.00001103102,0.00001091995,0.000190591,0.00002360272,0.0008770259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646438,"threshold_uncertainty_score":0.005507827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005336374852177865,"score_gpt":0.2448613152844827,"score_spread":0.2395249404323048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}