{"id":"W2101440707","doi":"10.1016/j.cllc.2015.05.010","title":"A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada); Regional Municipality of Durham; Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre; Ottawa Hospital; McGill University Health Centre; Juravinski Cancer Centre","funders":"","keywords":"Pemetrexed; Medicine; Internal medicine; Lung cancer; Oncology; Clinical endpoint; Adverse effect; Hazard ratio; Chemotherapy; Randomized controlled trial; Confidence interval; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002528552,0.002781877,0.00494513,0.0006330995,0.0006661476,0.001887108,0.001783178,0.00246026,0.0101617],"category_scores_gemma":[0.002519594,0.001378978,0.002585237,0.0006106074,0.002549453,0.002691989,0.0007138739,0.006919503,0.002245894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001350047,"about_ca_system_score_gemma":0.001689374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250212,"about_ca_topic_score_gemma":0.002653288,"domain_scores_codex":[0.9989157,0.0005413911,0.00005957429,0.0002457849,0.00006444939,0.0001732251],"domain_scores_gemma":[0.9982939,0.00047503,0.000271835,0.0001899865,0.0001080453,0.000661201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.985938,0.007830679,0.0001472009,0.0001538279,0.0003928481,0.00001380934,0.00002892618,0.0002073497,0.001193546,0.00006977472,0.0003732188,0.003650868],"study_design_scores_gemma":[0.9510317,0.04767227,0.0003745125,0.000008092969,0.0001682247,0.00001329863,0.00001521486,0.0002361705,0.0001448736,0.00009307497,0.0002317154,0.00001077601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839717,0.00229736,0.0009054485,0.001025425,0.001420294,0.005694435,0.001697632,0.0002015143,0.002786237],"genre_scores_gemma":[0.9776923,0.001810123,0.003106317,0.001500339,0.0008350543,0.007292018,0.002274955,0.00007128133,0.005417611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0101617,"threshold_uncertainty_score":0.03399426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08825096488267198,"score_gpt":0.4698113163662173,"score_spread":0.3815603514835453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}