{"id":"W2101460836","doi":"10.1124/jpet.107.134510","title":"MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7 H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Arthritis; Chemistry; Ibuprofen; Pharmacology; Sulfonyl; Antagonist; Hyperalgesia; Cyclooxygenase; Rheumatoid arthritis; Inflammation; Prostaglandin; Osteoarthritis; Antagonism; Medicine; Receptor; Enzyme; Internal medicine; Biochemistry; Nociception","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001710697,0.0003577019,0.0009707536,0.0003667802,0.0001888331,0.0000171982,0.00008040888,0.0002926955,0.00003265107],"category_scores_gemma":[0.00004956436,0.0003132373,0.0001213761,0.0001966615,0.0005698272,0.0003602563,0.00007949727,0.0006640368,8.914085e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648226,"about_ca_system_score_gemma":0.0002288442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000178427,"about_ca_topic_score_gemma":0.000004023317,"domain_scores_codex":[0.9971426,0.0007245213,0.001081541,0.0003150923,0.0003466531,0.0003896036],"domain_scores_gemma":[0.9984996,0.0002840177,0.0006713761,0.0001138099,0.0002073162,0.0002239293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004320891,0.0003342967,0.003519653,0.0001588712,0.0002692494,0.0001504117,0.008690642,0.0000619402,0.975571,0.00006380933,0.0002224377,0.006636746],"study_design_scores_gemma":[0.01061632,0.005060688,0.002450868,0.0002338733,0.0001153314,0.001432413,0.00132247,0.00212479,0.9751122,0.0002709536,0.000959007,0.0003010536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644074,0.03365145,0.000150945,0.0005927447,0.0003893996,0.0007140314,0.000008522647,0.00001819728,0.00006726495],"genre_scores_gemma":[0.971983,0.02505447,0.002102448,0.0005382406,0.0002206087,0.00003404505,0.000005486353,0.0000406504,0.00002111866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008596981,"threshold_uncertainty_score":0.999932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263479987313426,"score_gpt":0.2938477191153546,"score_spread":0.2712129192422203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}