{"id":"W2101460836","doi":"10.1124/jpet.107.134510","title":"MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7 H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Arthritis; Chemistry; Ibuprofen; Pharmacology; Sulfonyl; Antagonist; Hyperalgesia; Cyclooxygenase; Rheumatoid arthritis; Inflammation; Prostaglandin; Osteoarthritis; Antagonism; Medicine; Receptor; Enzyme; Internal medicine; Biochemistry; Nociception","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260248,0.0003458093,0.0004643624,0.0003437126,0.0002252614,0.0001603092,0.0005428906,0.0006085496,0.005468569],"category_scores_gemma":[0.0002108921,0.000206119,0.0002306602,0.000167861,0.0002776392,0.0003352955,0.0001905276,0.0007935835,0.002536177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637082,"about_ca_system_score_gemma":0.0002162795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005759784,"about_ca_topic_score_gemma":0.001247082,"domain_scores_codex":[0.9998617,0.00001946756,0.00001093002,0.00001717941,0.00002985236,0.00006086228],"domain_scores_gemma":[0.9999084,0.0000156337,0.00002791982,0.000008903462,0.00000747286,0.00003162659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002859936,0.0004826986,0.0003869954,0.0001879697,0.00003582388,0.0003406927,0.00002448133,0.0002646812,0.9578353,0.0004517152,0.002738224,0.03439149],"study_design_scores_gemma":[0.003395988,0.01807866,0.02384554,0.00007751981,0.0001398577,0.003167907,0.00007870708,0.002436691,0.910337,0.0004712705,0.03785896,0.0001119818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602824,0.007367217,0.005986804,0.001258163,0.0003999741,0.0002739819,0.002396922,0.001205568,0.02082903],"genre_scores_gemma":[0.9803874,0.004072791,0.003571597,0.0005512898,0.0002656689,0.0001811457,0.001737538,0.00005143918,0.009181087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005468569,"threshold_uncertainty_score":0.01829422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263479987313426,"score_gpt":0.2938477191153546,"score_spread":0.2712129192422203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}