{"id":"W2101526118","doi":"10.1091/mbc.e08-04-0345","title":"An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Pleckstrin homology domain; Biology; Cell biology; Biochemistry; Biophysics; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685314,0.0001289248,0.0002055721,0.0000613622,0.00008076044,0.000003045059,0.0002304498,0.0002057588,0.0000137363],"category_scores_gemma":[0.0002192503,0.00008828766,0.0001047169,0.000132288,0.0003661653,0.000003190255,0.0001957876,0.0001279353,9.374742e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001000189,"about_ca_system_score_gemma":0.00004363134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005188116,"about_ca_topic_score_gemma":0.00001367341,"domain_scores_codex":[0.9987016,0.0004230027,0.000286079,0.000318279,0.00008588664,0.0001851866],"domain_scores_gemma":[0.9993286,0.00004847999,0.0001006803,0.0003877306,0.00007579013,0.00005874315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008672792,0.00007618832,0.003278053,0.00001443747,0.000009816316,0.000004312292,0.0001147174,0.0002125254,0.9958228,0.0001385205,0.00003432323,0.000207503],"study_design_scores_gemma":[0.0003264577,0.0002229427,0.003061333,0.00002915408,0.00001196824,0.00003996136,0.00005923613,0.0001080857,0.9949747,0.0005412556,0.0005253477,0.00009958873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960112,0.0009168588,0.001876738,0.0007669427,0.00009263854,0.0002140483,0.00001447091,0.000003897753,0.0001032136],"genre_scores_gemma":[0.9981644,0.00004037865,0.001172408,0.0005339691,0.00003514596,0.00001083964,0.00001262634,0.00001142733,0.00001877327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002153241,"threshold_uncertainty_score":0.3600266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009668295200158782,"score_gpt":0.2745433465607869,"score_spread":0.2648750513606281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}