{"id":"W2101551423","doi":"10.1371/journal.pone.0091063","title":"Transfer of Intracellular HIV Nef to Endothelium Causes Endothelial Dysfunction","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; U.S. Department of Veterans Affairs; School of Medicine, Indiana University; National Institutes of Health; University of Pennsylvania; American Heart Association","keywords":"Jurkat cells; Cell biology; Endothelial stem cell; Transfection; Biology; Endothelium; Endothelial dysfunction; Population; Green fluorescent protein; Intracellular; Virology; Immunology; Cell culture; T cell; Medicine; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844916,0.0002826605,0.0002343574,0.0001209152,0.0001375242,0.0002763568,0.0002078889,0.0005120585,0.001307362],"category_scores_gemma":[0.0001527244,0.0001383471,0.0002432605,0.00006836462,0.0002207126,0.0001583453,0.0001693683,0.000656452,0.0002099197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001822295,"about_ca_system_score_gemma":0.0001296286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002739859,"about_ca_topic_score_gemma":0.0003267057,"domain_scores_codex":[0.9998684,0.00003099031,0.000008562653,0.00002665978,0.00003142027,0.00003385839],"domain_scores_gemma":[0.999896,0.00003173935,0.00002677086,0.00001817008,0.000007327072,0.00001998985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001804237,0.0001230342,0.0003725878,0.00003881787,0.000008214096,0.0001712671,0.0000137383,0.00003409243,0.996678,0.0002164115,0.00008550326,0.002077948],"study_design_scores_gemma":[0.0000599507,0.001217716,0.008738395,0.00001801963,0.00003310142,0.001453814,0.00004436299,0.001499781,0.98375,0.0001998494,0.002977835,0.000007140614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944466,0.001455748,0.002841962,0.0001300069,0.00005592038,0.00001850422,0.0000999743,0.00005671721,0.0008944616],"genre_scores_gemma":[0.99543,0.0008443927,0.001554939,0.00008980565,0.00001325289,0.00002459406,0.0001708459,0.000008805702,0.001863331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307362,"threshold_uncertainty_score":0.00437361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03211075811001788,"score_gpt":0.2504912377656366,"score_spread":0.2183804796556188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}