{"id":"W2101578637","doi":"10.2174/092986712803414141","title":"Nonviral Approach for Targeted Nucleic Acid Delivery","year":2012,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene delivery; Nucleic acid; Transfection; Genetic enhancement; Electroporation; Cationic liposome; Gene knockdown; Oligonucleotide; DNA; Plasmid; Biology; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879608,0.0006947695,0.0006858648,0.0009842335,0.0002458641,0.0005738543,0.0006834121,0.0006361188,0.004051508],"category_scores_gemma":[0.000154247,0.0002050216,0.0003591726,0.000656774,0.0003169729,0.000644776,0.0004638128,0.0008432018,0.003288603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005259637,"about_ca_system_score_gemma":0.0005408378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003492749,"about_ca_topic_score_gemma":0.0005585353,"domain_scores_codex":[0.9997764,0.00002666834,0.00001326515,0.00004507346,0.0001169002,0.00002164053],"domain_scores_gemma":[0.9999465,0.00001673486,0.0000110232,0.000004592726,0.00001523325,0.00000598969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007938607,0.0002190476,0.0001647296,0.008247716,0.00005768436,0.0007401308,0.0001290844,0.0004523088,0.369391,0.0180978,0.009902755,0.5925184],"study_design_scores_gemma":[0.00002410386,0.0003602027,0.0006171218,0.0005018027,0.00006159905,0.003114201,0.00005047039,0.0005768581,0.1768874,0.002726627,0.8150455,0.00003409312],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009497766,0.9196506,0.03839897,0.0004178547,0.001252847,0.0002516908,0.0001968172,0.0002372186,0.03009622],"genre_scores_gemma":[0.05801143,0.8743194,0.02263327,0.0008696818,0.0003465973,0.0003504762,0.0005421479,0.00006189412,0.04286515],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004051508,"threshold_uncertainty_score":0.01355362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06277982800155697,"score_gpt":0.3296279748397128,"score_spread":0.2668481468381559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}