{"id":"W2101578637","doi":"10.2174/092986712803414141","title":"Nonviral Approach for Targeted Nucleic Acid Delivery","year":2012,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene delivery; Nucleic acid; Transfection; Genetic enhancement; Electroporation; Cationic liposome; Gene knockdown; Oligonucleotide; DNA; Plasmid; Biology; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002508625,0.0006828753,0.001087682,0.00004882915,0.00009806625,0.00002631052,0.0007048019,0.0007053672,0.0001070182],"category_scores_gemma":[0.00007301765,0.0005733,0.0008189906,0.0001116197,0.0001590564,0.000006311707,0.0002186828,0.0005136912,0.00004248127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006676758,"about_ca_system_score_gemma":0.0003544795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001385933,"about_ca_topic_score_gemma":1.695576e-7,"domain_scores_codex":[0.9976083,0.00004836045,0.0006218125,0.0008046355,0.0002622267,0.0006546478],"domain_scores_gemma":[0.998506,0.00001952562,0.0003665797,0.0006733153,0.0001347759,0.000299822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005635586,0.0002154336,0.00000608119,0.02637818,0.0003061946,0.000002132372,0.00001737436,3.726536e-7,0.0132214,0.000001589747,0.01367904,0.9461159],"study_design_scores_gemma":[0.0003500679,0.0001048612,6.118151e-7,0.001750805,0.001088067,0.00008016297,0.00002990634,0.0000104591,0.009327642,0.000002285337,0.9866305,0.0006246558],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003554426,0.9960588,0.001022115,0.000003696036,0.0007774397,0.0005643996,0.0002701189,0.00002565003,0.0009223557],"genre_scores_gemma":[0.000931004,0.9834039,0.0002954302,0.00003254963,0.004528611,0.0003790973,0.009650098,0.00009411498,0.0006851811],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9729514,"threshold_uncertainty_score":0.9996718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06277982800155697,"score_gpt":0.3296279748397128,"score_spread":0.2668481468381559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}