{"id":"W2101580858","doi":"10.1200/jco.2007.12.6334","title":"Efficacy, Toxicity, and Quality of Life in Older Women With Early-Stage Breast Cancer Treated With Letrozole or Placebo After 5 Years of Tamoxifen: NCIC CTG Intergroup Trial MA.17","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"American Society of Clinical Oncology; Sanofi; AstraZeneca; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Letrozole; Breast cancer; Hazard ratio; Tamoxifen; Placebo; Quality of life (healthcare); Internal medicine; Adverse effect; Cancer; Gynecology; Oncology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617317,0.0006744965,0.001495519,0.0003974247,0.000306985,0.000523248,0.0005424183,0.0009418036,0.001535669],"category_scores_gemma":[0.001712736,0.0002124814,0.001002745,0.0003725473,0.0004559689,0.0003363817,0.0002174924,0.00109232,0.0001654189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000718636,"about_ca_system_score_gemma":0.0009973139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002070101,"about_ca_topic_score_gemma":0.005279378,"domain_scores_codex":[0.999442,0.0003706587,0.000034612,0.00004802084,0.00005381973,0.00005078545],"domain_scores_gemma":[0.9992867,0.0001604128,0.0002625123,0.00003954741,0.00003530489,0.0002155606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9490889,0.005998832,0.01549742,0.0004021671,0.00151983,0.00006297327,0.00007911494,0.0003190072,0.002553846,0.00005673692,0.0009861195,0.02343514],"study_design_scores_gemma":[0.7879735,0.144896,0.06275894,0.0001133719,0.001558155,0.0001112338,0.00004692324,0.0005679322,0.0006470238,0.0001066767,0.001197566,0.00002262008],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991969,0.006005151,0.00007931922,0.0002687158,0.00006585541,0.0006537399,0.0004071721,0.00001351932,0.000537399],"genre_scores_gemma":[0.9948956,0.00177115,0.0002643281,0.0004852394,0.0001686895,0.001023142,0.0008365066,0.000002986009,0.0005522858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002070101,"threshold_uncertainty_score":0.008553267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05876974179343134,"score_gpt":0.3899183421152935,"score_spread":0.3311486003218621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}