{"id":"W2101586744","doi":"10.1091/mbc.e06-03-0217","title":"Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Proinflammatory cytokine; Biology; NF-κB; Cell biology; Transcription factor; Phosphorylation; NFKB1; IκBα; IκB kinase; Inflammation; Enhancer; Signal transduction; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050895,0.0002635281,0.0002952475,0.0002197987,0.0001421674,0.0002106208,0.0001443384,0.0001413678,0.001618652],"category_scores_gemma":[0.00007766894,0.00009392119,0.0002067544,0.0001796617,0.0001882408,0.0001535971,0.000234602,0.0006172598,0.0003659666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371129,"about_ca_system_score_gemma":0.0001706681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003828764,"about_ca_topic_score_gemma":0.0006363546,"domain_scores_codex":[0.999935,0.00001423743,0.000005255944,0.000009569233,0.00001474285,0.00002114644],"domain_scores_gemma":[0.9999658,0.000005332079,0.000007651367,0.000003541337,0.000004782955,0.0000129976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004774142,0.0001119765,0.0002874171,0.000151642,0.000009580166,0.0001531142,0.00002368501,0.00007635597,0.9942026,0.0001555348,0.0001298006,0.00422097],"study_design_scores_gemma":[0.0001481829,0.001278216,0.01661374,0.00004229971,0.00007693111,0.0008651223,0.000184707,0.001717952,0.9638546,0.0005492702,0.01464997,0.00001884681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783332,0.0113436,0.005989065,0.0004291966,0.0001372293,0.00005316751,0.0004148162,0.0001738401,0.003125967],"genre_scores_gemma":[0.9892988,0.004919307,0.002271815,0.0001697226,0.000030711,0.00004698453,0.0002860807,0.00001859043,0.002958037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618652,"threshold_uncertainty_score":0.005414963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005154299189758357,"score_gpt":0.2341909496449371,"score_spread":0.2290366504551787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}