{"id":"W2101599998","doi":"10.1158/1535-7163.mct-09-0243","title":"Drug ratio–dependent antitumor activity of irinotecan and cisplatin combinations <i>in vitro</i> and <i>in vivo</i>","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Irinotecan; Cisplatin; In vivo; Pharmacology; Drug; In vitro; Cytotoxicity; Chemistry; Medicine; Liposome; Chemotherapy; Cancer; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002803179,0.0003652674,0.0003897358,0.0002786206,0.00008786145,0.0002436358,0.0001997459,0.0001687942,0.0006947999],"category_scores_gemma":[0.0002267355,0.0001966377,0.000200341,0.0002296866,0.0001669784,0.0002623273,0.0001361886,0.0004429589,0.0002101554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002817095,"about_ca_system_score_gemma":0.0002513919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003939136,"about_ca_topic_score_gemma":0.0006460872,"domain_scores_codex":[0.99972,0.0000905343,0.00002936154,0.00004771842,0.00007693739,0.00003534076],"domain_scores_gemma":[0.9998509,0.00004505382,0.00003853995,0.00001356201,0.0000281036,0.0000238521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380169,0.00005654313,0.0001684984,0.00002846097,0.00001025878,0.00001645696,0.00001090038,0.0002669703,0.9974297,0.00002951642,0.00003440252,0.001710345],"study_design_scores_gemma":[0.00001257924,0.0006478286,0.0008601032,0.00000158273,0.00001658332,0.00005858186,0.000004873846,0.000811538,0.9971624,0.0000081009,0.0004126356,0.000003090713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938223,0.001933085,0.002211329,0.00005222202,0.00001581698,0.0000518669,0.0001721122,0.00007300593,0.001668048],"genre_scores_gemma":[0.9944416,0.001022961,0.003207854,0.00003108335,0.000008098104,0.00006129895,0.0002718738,0.00001937456,0.0009358912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006947999,"threshold_uncertainty_score":0.002324402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875205029635636,"score_gpt":0.3266822291234521,"score_spread":0.3079301788270958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}