{"id":"W2101599998","doi":"10.1158/1535-7163.mct-09-0243","title":"Drug ratio–dependent antitumor activity of irinotecan and cisplatin combinations <i>in vitro</i> and <i>in vivo</i>","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Irinotecan; Cisplatin; In vivo; Pharmacology; Drug; In vitro; Cytotoxicity; Chemistry; Medicine; Liposome; Chemotherapy; Cancer; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953414,0.0001508376,0.0003472312,0.0001589541,0.00004149247,0.0000162614,0.00006293927,0.00004682623,0.000006813242],"category_scores_gemma":[0.00001477325,0.0001425803,0.00003393763,0.0002658544,0.0001346956,0.00006603387,0.00004397821,0.0002362592,2.255074e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524716,"about_ca_system_score_gemma":0.0001293024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000354561,"about_ca_topic_score_gemma":0.000357149,"domain_scores_codex":[0.9988867,0.00007280699,0.0002062114,0.0002615352,0.0003199568,0.0002528097],"domain_scores_gemma":[0.999543,0.00004675838,0.0000680457,0.0002043219,0.00007173561,0.00006616513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004387306,0.0003398665,0.007252231,0.000110475,0.00006645879,0.0000689388,0.0005856142,0.00003868677,0.9716805,0.0002237907,0.00002270883,0.01917202],"study_design_scores_gemma":[0.004234185,0.0002433711,0.0535774,0.000160619,0.00008138512,0.00001198637,0.00008760495,0.001316682,0.9391633,0.0004316868,0.0005179433,0.0001738143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858716,0.006388355,0.0002443351,0.006201064,0.00003608386,0.000560583,0.00002769592,0.00001497423,0.0006553064],"genre_scores_gemma":[0.9962676,0.002270774,0.0001750387,0.001094319,0.0000132136,0.00003572761,0.000001879072,0.00001467332,0.0001268004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04632517,"threshold_uncertainty_score":0.5814254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875205029635636,"score_gpt":0.3266822291234521,"score_spread":0.3079301788270958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}