{"id":"W2101605059","doi":"10.1038/nature10405","title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2070,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Agence Nationale de la Recherche; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Fogarty International Center; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research; National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Agency for Healthcare Research and Quality; National Institutes of Health; National Institute of General Medical Sciences; Kidney Research UK; British Heart Foundation; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Blood pressure; Genome-wide association study; Pulse pressure; Internal medicine; Medicine; Prehypertension; Stroke (engine); Cardiology; Disease; Kidney disease; Coronary artery disease; Biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008954595,0.0008686574,0.000509677,0.001045236,0.0004330152,0.0009336406,0.0006744058,0.00129375,0.003939909],"category_scores_gemma":[0.002967759,0.0005102985,0.0008674523,0.001433783,0.0006268289,0.0006198336,0.0004515899,0.001078889,0.0003624446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805347,"about_ca_system_score_gemma":0.0004009467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00213089,"about_ca_topic_score_gemma":0.0027342,"domain_scores_codex":[0.9989693,0.000343519,0.0001067471,0.0002990682,0.00018272,0.00009867913],"domain_scores_gemma":[0.9975678,0.001138533,0.0007123643,0.0002406766,0.0001589806,0.0001816036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002531162,0.0003011856,0.9176854,0.000205949,0.003607568,0.004070188,0.0003510722,0.00123002,0.04065878,0.004214901,0.001342564,0.02380129],"study_design_scores_gemma":[0.0002111619,0.0002492846,0.9704121,0.00008675486,0.001806341,0.004652257,0.000183694,0.003770827,0.006346988,0.009048564,0.00318162,0.0000504333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781402,0.005524771,0.00824434,0.002275436,0.0003095524,0.00002628258,0.001502533,0.0001206174,0.003856189],"genre_scores_gemma":[0.9924178,0.001814744,0.003284775,0.0003480843,0.0002957219,0.00001881266,0.0004400428,0.00003612226,0.001343786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003939909,"threshold_uncertainty_score":0.01318026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008489283796232832,"score_gpt":0.2093351281908452,"score_spread":0.2008458443946123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}