{"id":"W2101649073","doi":"10.4049/jimmunol.1003414","title":"CpG and Non-CpG Oligodeoxynucleotides Directly Costimulate Mouse and Human CD4+ T Cells through a TLR9- and MyD88-Independent Mechanism","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; National Science Foundation","keywords":"TLR9; CpG Oligodeoxynucleotide; CD28; Cell biology; T-cell receptor; Biology; Cytokine; Jurkat cells; T cell; Downregulation and upregulation; CpG site; Secretion; Phosphorylation; Immunology; Immune system; Biochemistry; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009091457,0.0002365834,0.0004782275,0.0001595973,0.0003967598,0.0000231585,0.0002609407,0.0002921769,0.0002058775],"category_scores_gemma":[0.00005068884,0.0001616927,0.00006512989,0.00006175243,0.0005480855,0.000293039,0.000228134,0.0005634149,0.00004189117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000025884,"about_ca_system_score_gemma":0.00003763493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000318628,"about_ca_topic_score_gemma":0.00002076797,"domain_scores_codex":[0.9983308,0.0005408778,0.0005769079,0.0001635901,0.00004717909,0.0003406729],"domain_scores_gemma":[0.9988505,0.0002394501,0.0005016597,0.0002618177,0.0001221062,0.00002441544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115505,0.00006447641,0.0001825735,0.00001287406,0.0005192346,0.00001824703,0.005066748,0.000001133885,0.9884395,0.003188032,0.0001465354,0.001205591],"study_design_scores_gemma":[0.002770059,0.001449045,0.01685773,0.00006496585,0.0002427031,0.001910431,0.001128525,0.000004650702,0.9681387,0.005819247,0.001394955,0.0002189711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911268,0.007109921,0.0004004998,0.0002116094,0.0003700952,0.0001959268,0.000003416537,0.00001876507,0.0005629862],"genre_scores_gemma":[0.994462,0.004433165,0.0001369642,0.0001380529,0.0000243531,0.000004923274,0.000002346311,0.00002282655,0.0007753855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02030079,"threshold_uncertainty_score":0.6593636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448525405195036,"score_gpt":0.2239823011958776,"score_spread":0.2094970471439272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}