{"id":"W2101649073","doi":"10.4049/jimmunol.1003414","title":"CpG and Non-CpG Oligodeoxynucleotides Directly Costimulate Mouse and Human CD4+ T Cells through a TLR9- and MyD88-Independent Mechanism","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; National Science Foundation","keywords":"TLR9; CpG Oligodeoxynucleotide; CD28; Cell biology; T-cell receptor; Biology; Cytokine; Jurkat cells; T cell; Downregulation and upregulation; CpG site; Secretion; Phosphorylation; Immunology; Immune system; Biochemistry; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769051,0.0004808222,0.000202803,0.0001578231,0.00007660765,0.000160846,0.0001252436,0.0003004608,0.001346326],"category_scores_gemma":[0.0001401439,0.0001165955,0.0001648918,0.0001350534,0.0001657308,0.0001173888,0.0001700053,0.0005501998,0.0003009855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524124,"about_ca_system_score_gemma":0.0001986076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001534658,"about_ca_topic_score_gemma":0.0004721242,"domain_scores_codex":[0.9998036,0.00005891554,0.00001482825,0.00003232103,0.00004701351,0.00004349167],"domain_scores_gemma":[0.9999293,0.00002424895,0.0000144317,0.000008206665,0.000006990213,0.00001675054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001881462,0.00006201622,0.00009481377,0.00007235484,0.000005831196,0.00002097707,0.0000066905,0.00009570935,0.9972094,0.00009017596,0.00003094187,0.002122934],"study_design_scores_gemma":[0.000038314,0.001191918,0.0008736546,0.000007642803,0.00001834176,0.0001541884,0.00001101589,0.0003561304,0.9955618,0.00006685886,0.001717827,0.000002199534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861094,0.00333063,0.006915536,0.0001099051,0.00009468661,0.0002005567,0.0003996916,0.0000465026,0.002793097],"genre_scores_gemma":[0.984189,0.001937484,0.01078698,0.0001724497,0.00003936178,0.0001918414,0.000607743,0.00001830839,0.002056937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346326,"threshold_uncertainty_score":0.004503906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448525405195036,"score_gpt":0.2239823011958776,"score_spread":0.2094970471439272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}