{"id":"W2101657719","doi":"10.1158/1535-7163.mct-13-0401","title":"Microtubule Dynamics Control Tail Retraction in Migrating Vascular Endothelial Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Alberta Innovates; National Institutes of Health; University of Calgary","keywords":"Microtubule; Cell biology; Nocodazole; Motility; Lamellipodium; Biology; Cytoskeleton; Microtubule polymerization; Paclitaxel; Angiogenesis; Colchicine; Cell migration; Biophysics; Cell; Chemistry; Tubulin; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000163242,0.0003057586,0.0002582711,0.00008548026,0.00007739447,0.00007568154,0.0002786109,0.0003702159,0.0000737033],"category_scores_gemma":[0.0000128062,0.0003184729,0.0002010905,0.0001295761,0.00007322155,0.00001065585,0.00005598495,0.0002975502,0.00002981459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326427,"about_ca_system_score_gemma":0.0001130848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007421394,"about_ca_topic_score_gemma":0.001461568,"domain_scores_codex":[0.9983188,0.0001338785,0.0003686838,0.00049028,0.0002005249,0.0004878643],"domain_scores_gemma":[0.9991393,0.00001520605,0.0001410119,0.0004917994,0.000128287,0.00008435895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003593459,0.00009102461,0.003016079,0.00002326254,0.0001634958,0.000005684839,0.00007079048,0.001172412,0.9879327,0.00004850674,0.0001828558,0.007257251],"study_design_scores_gemma":[0.002187621,0.000174967,0.001619447,0.00004392467,0.0001036108,0.000009844779,0.0001647504,0.01194897,0.9485646,0.0001325407,0.03445779,0.0005919528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746539,0.0029245,0.02040641,0.0003151078,0.000431955,0.0007684886,0.00009008984,0.00002681844,0.0003827219],"genre_scores_gemma":[0.9941158,0.001320264,0.0009226532,0.002667335,0.0001872328,0.000224085,0.0001055179,0.00008184971,0.0003752796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03936813,"threshold_uncertainty_score":0.9999267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006482326832698986,"score_gpt":0.2305935236054468,"score_spread":0.2241111967727478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}