{"id":"W2101671356","doi":"10.2217/14622416.9.2.215","title":"Epigenetics of Cancer Progression","year":2008,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Epigenetics; DNA methylation; Biology; Gene silencing; Cancer; Methylation; Gene; CpG site; Epigenetic therapy; Cancer epigenetics; Cancer research; Genetics; Bioinformatics; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004772744,0.0006899968,0.00101507,0.0009329542,0.000358425,0.0009917179,0.000964294,0.0011795,0.003186578],"category_scores_gemma":[0.000517452,0.0001983146,0.0003128872,0.0009815113,0.0009480588,0.001127888,0.0007632556,0.001584948,0.002495728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009708465,"about_ca_system_score_gemma":0.000899269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139663,"about_ca_topic_score_gemma":0.00183595,"domain_scores_codex":[0.9998075,0.00005016647,0.00001657233,0.00003573991,0.0000724011,0.00001771501],"domain_scores_gemma":[0.9998055,0.00007141853,0.00002744416,0.0000134813,0.00005675906,0.00002548928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007127853,0.00003458434,0.0004934394,0.004830853,0.00007749425,0.0004690156,0.0001622415,0.0007620495,0.008812333,0.02068079,0.037749,0.9258571],"study_design_scores_gemma":[0.00000957154,0.00003870198,0.001033681,0.0006055065,0.00002448637,0.001679807,0.00005959118,0.00009608448,0.001833162,0.006039053,0.9885661,0.00001428027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000296256,0.9941807,0.0008159541,0.0008233624,0.000472493,0.00000761813,0.00002343568,0.00002259594,0.003357549],"genre_scores_gemma":[0.003731182,0.9908827,0.0005568974,0.000520113,0.0004498748,0.00001610801,0.00004371809,0.000004190084,0.003795191],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003186578,"threshold_uncertainty_score":0.01066017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0590591869217894,"score_gpt":0.431457879482585,"score_spread":0.3723986925607956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}