{"id":"W2101671356","doi":"10.2217/14622416.9.2.215","title":"Epigenetics of Cancer Progression","year":2008,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Epigenetics; DNA methylation; Biology; Gene silencing; Cancer; Methylation; Gene; CpG site; Epigenetic therapy; Cancer epigenetics; Cancer research; Genetics; Bioinformatics; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009905163,0.0003401046,0.0007127131,0.00008687685,0.00005756574,0.000007985093,0.0003222183,0.0003334646,0.00003244334],"category_scores_gemma":[0.00002048429,0.000305894,0.0004227907,0.0001255609,0.00008707945,0.000001136557,0.0001741909,0.0001524334,0.00001020515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003271283,"about_ca_system_score_gemma":0.0004166182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007088038,"about_ca_topic_score_gemma":0.000003431724,"domain_scores_codex":[0.9985096,0.000100863,0.0005924952,0.0004069135,0.000149813,0.0002402557],"domain_scores_gemma":[0.9988658,0.00001825346,0.0005418201,0.0003649962,0.0001072402,0.0001018881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001012199,0.00005582976,0.00004605555,0.001794229,0.0002091802,0.000002164553,0.00001263677,0.00003882375,0.01101528,0.000003525974,0.0002309207,0.9865812],"study_design_scores_gemma":[0.0001670827,0.00006646934,0.000002130388,0.0005174343,0.0003133244,0.000005147111,0.000001076238,0.000009164639,0.04623866,0.000006948884,0.9523766,0.000295942],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001087034,0.9972259,0.0001681359,0.00000253997,0.0004087326,0.0005260468,0.0002110225,0.000007435441,0.0003631331],"genre_scores_gemma":[0.0001059439,0.9973993,0.001012587,0.00001279144,0.0006075028,0.00009481859,0.0004704708,0.00009199551,0.0002045951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9862853,"threshold_uncertainty_score":0.9999393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0590591869217894,"score_gpt":0.431457879482585,"score_spread":0.3723986925607956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}