{"id":"W2101723423","doi":"10.1074/jbc.m305352200","title":"Overexpression of Interferon-γ-inducible GTPase Inhibits Coxsackievirus B3-induced Apoptosis through the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway and Inhibition of Viral Replication","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Protein kinase B; LY294002; PI3K/AKT/mTOR pathway; Kinase; Cell biology; Phosphorylation; Biology; GSK-3; Molecular biology; Signal transduction; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004902094,0.0001087506,0.0003176806,0.00002813633,0.00007908996,0.000005907039,0.00009773603,0.0002330832,0.00005519087],"category_scores_gemma":[0.001017021,0.00005367908,0.0001485283,0.0002172762,0.0002806553,0.00011371,0.00006585586,0.0004485316,2.724454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004980498,"about_ca_system_score_gemma":0.00009344294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001999924,"about_ca_topic_score_gemma":9.001111e-8,"domain_scores_codex":[0.998767,0.0001423685,0.0006157563,0.0001518459,0.0002070804,0.0001159292],"domain_scores_gemma":[0.9983431,0.000123358,0.0008011413,0.0003242917,0.0003726885,0.00003540179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004576566,0.0003307189,0.003452704,0.00009414871,0.00004878733,3.074789e-7,0.00008675433,0.000002733964,0.9938329,0.00008291953,0.00006225412,0.001548061],"study_design_scores_gemma":[0.0009099904,0.0009031712,0.006396542,0.0005828995,0.00002893815,0.00003896224,0.0003148947,0.000008160844,0.9903706,0.0002870706,0.0001095708,0.00004922638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982601,0.0003566525,0.00005290686,0.0004020189,0.00003711916,0.0001926809,0.000007188503,0.000003567371,0.0006877121],"genre_scores_gemma":[0.9995549,0.0002255002,0.0000834551,0.00004876907,0.0000404162,0.000006014703,0.000004947479,0.000005332563,0.0000306212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00346238,"threshold_uncertainty_score":0.2188969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04976563452343107,"score_gpt":0.3108386801031102,"score_spread":0.2610730455796791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}