{"id":"W2101723423","doi":"10.1074/jbc.m305352200","title":"Overexpression of Interferon-γ-inducible GTPase Inhibits Coxsackievirus B3-induced Apoptosis through the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway and Inhibition of Viral Replication","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Protein kinase B; LY294002; PI3K/AKT/mTOR pathway; Kinase; Cell biology; Phosphorylation; Biology; GSK-3; Molecular biology; Signal transduction; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184594,0.0004078613,0.0002781081,0.0002372687,0.0001733316,0.000271552,0.0002375861,0.0002659198,0.0008667285],"category_scores_gemma":[0.00009545377,0.0001329361,0.0003515049,0.0002085782,0.0002387594,0.0001489197,0.0001663718,0.0007403942,0.0002948739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003186848,"about_ca_system_score_gemma":0.0002965189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025026,"about_ca_topic_score_gemma":0.001231703,"domain_scores_codex":[0.9998553,0.0000236781,0.00001813667,0.0000216957,0.00003456158,0.00004661533],"domain_scores_gemma":[0.9999269,0.00001207267,0.00002030887,0.00001018346,0.00000800298,0.00002260432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002545623,0.000101671,0.0000873543,0.00003648205,0.000006331794,0.00002423797,0.00001917615,0.00005273218,0.9983609,0.00008919868,0.00004712487,0.0009201932],"study_design_scores_gemma":[0.00009482648,0.0006651363,0.003437433,0.00001260522,0.00002120171,0.0001042869,0.00002597631,0.001516111,0.9921188,0.00004397783,0.00195466,0.000004903394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952753,0.001466678,0.001195349,0.0001096102,0.00004208741,0.0000416629,0.0002875313,0.0000859918,0.001495769],"genre_scores_gemma":[0.9944576,0.001012738,0.00171064,0.00004472993,0.00001252249,0.00007017665,0.0007882418,0.00001914856,0.001884103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025026,"threshold_uncertainty_score":0.002899528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04976563452343107,"score_gpt":0.3108386801031102,"score_spread":0.2610730455796791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}