{"id":"W2101725481","doi":"10.1158/1055-9965.epi-07-0658","title":"The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial","year":2008,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Placebo; Prostate; Putrescine; Prostate cancer; Prostate-specific antigen; Urology; Ornithine decarboxylase; Polyamine; Prostate biopsy; Ornithine; Internal medicine; Randomized controlled trial; Gastroenterology; Endocrinology; Pathology; Chemistry; Cancer; Arginine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002451689,0.001553056,0.003436947,0.0004404635,0.00056587,0.001148701,0.0009246974,0.002740084,0.004540272],"category_scores_gemma":[0.001768544,0.0007594162,0.00251027,0.0005426772,0.001046619,0.0007794032,0.0003397792,0.002121395,0.0006620778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007784828,"about_ca_system_score_gemma":0.001011841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00166662,"about_ca_topic_score_gemma":0.002999883,"domain_scores_codex":[0.9990858,0.0005130486,0.00005421883,0.0001415568,0.00006631333,0.0001390637],"domain_scores_gemma":[0.9987978,0.0002640123,0.0003448447,0.00009751879,0.00008868388,0.0004071868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9807236,0.004090221,0.00100181,0.0004602697,0.001233854,0.00002162995,0.00003739874,0.0001232935,0.001916924,0.00002697372,0.0004423741,0.009921647],"study_design_scores_gemma":[0.8992074,0.09318168,0.005917068,0.00004053346,0.0007779749,0.00002786116,0.00002197426,0.00010861,0.0002148459,0.00005677258,0.0004325584,0.00001271214],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790496,0.01480636,0.0004190467,0.0009026043,0.0003834881,0.001984366,0.001088305,0.0001034555,0.001262683],"genre_scores_gemma":[0.9827634,0.006957791,0.001347806,0.00200682,0.0006935516,0.002605942,0.001205532,0.00002406266,0.002394972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004540272,"threshold_uncertainty_score":0.01518869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566791082582933,"score_gpt":0.3411413616499638,"score_spread":0.3254734508241345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}