{"id":"W2101725481","doi":"10.1158/1055-9965.epi-07-0658","title":"The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial","year":2008,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Placebo; Prostate; Putrescine; Prostate cancer; Prostate-specific antigen; Urology; Ornithine decarboxylase; Polyamine; Prostate biopsy; Ornithine; Internal medicine; Randomized controlled trial; Gastroenterology; Endocrinology; Pathology; Chemistry; Cancer; Arginine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005848367,0.0002039011,0.0009502398,0.00008227932,0.0001008966,0.000003182604,0.0001307489,0.0001762751,0.000003830915],"category_scores_gemma":[0.006585862,0.0001346548,0.0003081409,0.0001495683,0.0005077592,0.000008294732,0.0000531388,0.00009444208,3.861161e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001854097,"about_ca_system_score_gemma":0.00006495154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498618,"about_ca_topic_score_gemma":0.00005940966,"domain_scores_codex":[0.9958312,0.002367356,0.001081761,0.0003828959,0.00009231694,0.0002444843],"domain_scores_gemma":[0.9962171,0.00251639,0.000843255,0.0003114389,0.00005348563,0.00005833578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8935556,0.0001454599,0.001691892,0.00003542722,0.0003940207,5.866628e-7,0.00003773321,0.000009109032,0.08950936,0.00005737614,0.0002245006,0.01433891],"study_design_scores_gemma":[0.8915057,0.001333182,0.009583666,0.0001189635,0.0002651751,0.000005716437,0.00001866744,0.0002187983,0.09595601,0.0005926918,0.0002426446,0.0001587694],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872442,0.008757692,0.0003738186,0.0004271016,0.0001590242,0.00285212,0.00003488926,0.000007219306,0.0001438595],"genre_scores_gemma":[0.9931042,0.004591994,0.0004197974,0.00001902508,0.0001128607,0.001012459,0.0001240272,0.00001478493,0.0006008868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01418014,"threshold_uncertainty_score":0.7884368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566791082582933,"score_gpt":0.3411413616499638,"score_spread":0.3254734508241345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}