{"id":"W2101753805","doi":"10.4049/jimmunol.1500542","title":"The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Genentech","keywords":"Inflammasome; Necroptosis; Inflammation; RIPK1; Immunology; NLRP1; Pathogenesis; Pyroptosis; Signal transducing adaptor protein; NALP3; Signal transduction; Biology; Innate immune system; Caspase; Programmed cell death; Apoptosis; Cell biology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003384412,0.0008547702,0.0004058424,0.0009114515,0.0002435898,0.0005686574,0.0002721647,0.0004832908,0.002005086],"category_scores_gemma":[0.0002058303,0.0004222326,0.000459191,0.0002582949,0.0005350602,0.0004816003,0.0003681339,0.001488983,0.0006504122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003629842,"about_ca_system_score_gemma":0.0002197213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002486804,"about_ca_topic_score_gemma":0.0005431657,"domain_scores_codex":[0.9996804,0.0000643225,0.00005431358,0.00008889483,0.00005608382,0.0000559587],"domain_scores_gemma":[0.9996824,0.00003472567,0.0001358936,0.00002683932,0.0000151912,0.0001050183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409278,0.0000496292,0.0002588258,0.00004990981,0.000005938583,0.0001310839,0.00002542843,0.00004585043,0.9981331,0.0001544679,0.00003570518,0.0008690528],"study_design_scores_gemma":[0.0003038886,0.001376983,0.0310666,0.00008829631,0.00009224527,0.003327925,0.0001898812,0.002270495,0.9563887,0.0004422553,0.00442844,0.00002430619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892437,0.002288122,0.00545825,0.0002198208,0.00004234549,0.00008349257,0.0007833315,0.0002363326,0.001644624],"genre_scores_gemma":[0.9903601,0.001688546,0.003842755,0.00009763885,0.00002209562,0.00007779045,0.0005292601,0.00004278526,0.00333897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005086,"threshold_uncertainty_score":0.006707728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143433954562781,"score_gpt":0.2474327210238038,"score_spread":0.2330893255675257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}