{"id":"W2101770554","doi":"10.1128/aac.46.6.1851-1856.2002","title":"A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council; Medical Research Council Canada; amfAR, The Foundation for AIDS Research; Howard Hughes Medical Institute","keywords":"Reverse-transcriptase inhibitor; Efavirenz; Virology; Reverse transcriptase; Nevirapine; Virus; Extracellular; Biology; Infectivity; Cell culture; Lentivirus; Molecular biology; Viral load; Viral disease; RNA; Biochemistry; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602026,0.0003854969,0.0007386904,0.0001629157,0.0001840111,0.0005767319,0.0003611481,0.0004714475,0.000914091],"category_scores_gemma":[0.0004430411,0.0003015429,0.0003646108,0.0001656656,0.0002914695,0.0005614694,0.0003870185,0.0005277251,0.0002451957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003259761,"about_ca_system_score_gemma":0.0002218532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002495175,"about_ca_topic_score_gemma":0.002477469,"domain_scores_codex":[0.9994196,0.00009652152,0.00005144281,0.00007311322,0.0002118173,0.0001475029],"domain_scores_gemma":[0.9997599,0.00006032178,0.00007204214,0.0000315803,0.00003537295,0.00004081093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001505501,0.00004559522,0.0003840725,0.00005918427,0.00001754417,0.00003772861,0.00001542868,0.000206318,0.9971726,0.0001069912,0.00002450563,0.001779487],"study_design_scores_gemma":[0.00003845615,0.0016152,0.01620997,0.00001641749,0.00003775048,0.000484512,0.00004485949,0.003052059,0.976305,0.0001155148,0.00206335,0.00001706242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920759,0.00367816,0.002344526,0.00002569951,0.00001768356,0.0000454941,0.0001776897,0.00003931461,0.001595341],"genre_scores_gemma":[0.9973831,0.0007053522,0.001192379,0.00002839292,0.00000524561,0.0000172768,0.0002113347,0.000006812527,0.0004501851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002495175,"threshold_uncertainty_score":0.004961312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928421855919847,"score_gpt":0.2750010061534755,"score_spread":0.255716787594277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}