{"id":"W2101770554","doi":"10.1128/aac.46.6.1851-1856.2002","title":"A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council; Medical Research Council Canada; amfAR, The Foundation for AIDS Research; Howard Hughes Medical Institute","keywords":"Reverse-transcriptase inhibitor; Efavirenz; Virology; Reverse transcriptase; Nevirapine; Virus; Extracellular; Biology; Infectivity; Cell culture; Lentivirus; Molecular biology; Viral load; Viral disease; RNA; Biochemistry; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000682383,0.0002033992,0.0004190665,0.0001383616,0.0001310962,0.00001331394,0.00004687269,0.0001073194,0.0003748081],"category_scores_gemma":[0.000003747185,0.000179753,0.000168331,0.0001766643,0.0001116389,0.0001217033,0.00001384556,0.0000774828,0.000005722938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003209047,"about_ca_system_score_gemma":0.00002384413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001251381,"about_ca_topic_score_gemma":0.000005595111,"domain_scores_codex":[0.9989871,0.00001640245,0.0003422708,0.0002767579,0.0001575544,0.0002199359],"domain_scores_gemma":[0.9995158,0.00001075857,0.0001742932,0.0001573311,0.00008357609,0.00005820125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003303514,0.001088651,0.003118366,0.0001930207,0.0001762472,0.000007652093,0.002434146,7.530917e-7,0.9714211,0.00001584112,0.01935687,0.001856968],"study_design_scores_gemma":[0.004760776,0.0002293724,0.001619928,0.0002251016,0.0001244681,0.00001190914,0.00004242062,0.0001644972,0.9876592,0.00001132618,0.004974823,0.0001761483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977092,0.00003782307,0.0001042613,0.00120646,0.0001049532,0.0005065693,0.0001265373,0.0000192621,0.0001849026],"genre_scores_gemma":[0.9969844,0.0007033912,0.0006234758,0.0004398836,0.00004689691,0.000005125308,0.00005400638,0.00003030361,0.001112552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0162381,"threshold_uncertainty_score":0.7330115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928421855919847,"score_gpt":0.2750010061534755,"score_spread":0.255716787594277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}