{"id":"W2101784151","doi":"10.1115/1.4029551","title":"Epigenetic Changes During Mechanically Induced Osteogenic Lineage Commitment","year":2015,"lang":"en","type":"article","venue":"Journal of Biomechanical Engineering","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; New York State Stem Cell Science","keywords":"Epigenetics; DNA methylation; Biology; Gene expression; Methylation; Bisulfite sequencing; Gene; Cell biology; Adipogenesis; Stimulation; Regulation of gene expression; Molecular biology; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417794,0.0001702674,0.0002046218,0.0002278809,0.0001542167,0.0002326087,0.0001322462,0.0002017984,0.001769736],"category_scores_gemma":[0.0002603403,0.0001886733,0.0001730671,0.0001785021,0.0002136841,0.000174754,0.0002753736,0.0004141783,0.0002565535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273211,"about_ca_system_score_gemma":0.0001777843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007178396,"about_ca_topic_score_gemma":0.001400766,"domain_scores_codex":[0.9998193,0.00002582461,0.00001765988,0.0000326401,0.00007446745,0.00003004763],"domain_scores_gemma":[0.9998719,0.00003127729,0.0000361406,0.00001171188,0.00003121674,0.00001781579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004280921,0.000006504728,0.0003078459,0.00001810769,0.000002566836,0.00002720224,0.00001892385,0.00002205078,0.9984196,0.00004243234,0.00001655207,0.001075162],"study_design_scores_gemma":[0.000006999865,0.0001399322,0.03591714,0.000009480532,0.00001187908,0.0001019109,0.00007164507,0.0003862686,0.9609671,0.0000783342,0.002303006,0.000006386636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870826,0.003718108,0.00491189,0.0001509753,0.00005324717,0.00005925859,0.0007579574,0.00006403887,0.003201753],"genre_scores_gemma":[0.9916095,0.001354521,0.002547557,0.0001307097,0.00001924349,0.00009001743,0.0006236102,0.00001928672,0.003605441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001769736,"threshold_uncertainty_score":0.005920291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02345079174519313,"score_gpt":0.2526011008842053,"score_spread":0.2291503091390122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}