{"id":"W2101784151","doi":"10.1115/1.4029551","title":"Epigenetic Changes During Mechanically Induced Osteogenic Lineage Commitment","year":2015,"lang":"en","type":"article","venue":"Journal of Biomechanical Engineering","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; New York State Stem Cell Science","keywords":"Epigenetics; DNA methylation; Biology; Gene expression; Methylation; Bisulfite sequencing; Gene; Cell biology; Adipogenesis; Stimulation; Regulation of gene expression; Molecular biology; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006288628,0.0001797462,0.0002560292,0.0001476606,0.00003001877,0.0000282625,0.0002561331,0.0002015692,0.00000711856],"category_scores_gemma":[0.0002990509,0.0001640401,0.0001404513,0.0001637708,0.000009078327,0.000005939286,0.0001393981,0.0001849269,0.000004808068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005657313,"about_ca_system_score_gemma":0.00007385882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002538016,"about_ca_topic_score_gemma":0.000005190187,"domain_scores_codex":[0.9987276,0.0000476141,0.0004644142,0.000185993,0.0003121133,0.0002622459],"domain_scores_gemma":[0.9989588,0.00001882148,0.0002245876,0.0002430081,0.0002229705,0.0003318536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006612712,0.0000507983,0.00002136374,0.00001717959,0.00007103408,0.00001605452,0.00002435178,0.001130425,0.9971734,0.00003880131,0.00001262264,0.001377882],"study_design_scores_gemma":[0.001020098,0.001276656,0.0001803409,0.00003652165,0.00003459559,0.00004901126,0.00002914105,0.0009235612,0.9932612,0.00005473627,0.002941847,0.000192286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625916,0.002083122,0.03432669,0.0001797991,0.0006663257,0.0001114735,0.000003581402,0.00001190399,0.00002549851],"genre_scores_gemma":[0.9940915,0.0003121138,0.004754243,0.00003779611,0.0007189129,0.000004741936,0.000007047745,0.00003615548,0.00003751188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03149987,"threshold_uncertainty_score":0.6689363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02345079174519313,"score_gpt":0.2526011008842053,"score_spread":0.2291503091390122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}