{"id":"W2101878110","doi":"10.1371/journal.pone.0019768","title":"Synaptically-Competent Neurons Derived from Canine Embryonic Stem Cells by Lineage Selection with EGF and Noggin","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Guelph","funders":"OVC Pet Trust; Natural Sciences and Engineering Research Council of Canada","keywords":"Noggin; Biology; Neural stem cell; Neurosphere; Cell biology; Stem cell; Embryonic stem cell; Cellular differentiation; Progenitor cell; SOX2; Nestin; Adult stem cell; Genetics; Bone morphogenetic protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313189,0.0003133119,0.000265558,0.000317685,0.0001463139,0.000316714,0.0003118404,0.000222215,0.001107093],"category_scores_gemma":[0.0001581122,0.0002103479,0.0002527924,0.0001916132,0.0001966195,0.0001474405,0.000360407,0.000560392,0.0007165424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081965,"about_ca_system_score_gemma":0.0002965528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007102238,"about_ca_topic_score_gemma":0.002009032,"domain_scores_codex":[0.9997827,0.00001365849,0.00003807499,0.00004462116,0.00008751434,0.00003351286],"domain_scores_gemma":[0.9998579,0.00002009779,0.00002869469,0.00002421509,0.00004082342,0.00002817569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003487111,0.00001007649,0.00031283,0.00004272249,0.000003285074,0.0001062742,0.00004338832,0.00005939281,0.997794,0.0001627589,0.00006604096,0.001364291],"study_design_scores_gemma":[0.00001292323,0.0001825791,0.00467772,0.00002047942,0.00002965297,0.0008598082,0.00005878814,0.001176088,0.9826758,0.00008994615,0.01020894,0.000007298117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969997,0.001125676,0.02084762,0.00008941101,0.00007555906,0.0002742814,0.001443569,0.0002177103,0.005929164],"genre_scores_gemma":[0.9514611,0.00173454,0.03086311,0.00007103424,0.00002277884,0.0003196952,0.006081712,0.0001519784,0.009294164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107093,"threshold_uncertainty_score":0.003703594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655736048269643,"score_gpt":0.2010259506981236,"score_spread":0.1744685902154272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}