{"id":"W2101885674","doi":"10.1016/j.molcel.2010.05.017","title":"Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition","year":2010,"lang":"en","type":"article","venue":"Molecular Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":401,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors; Sirolimus; Computational biology; Cell biology; Signal transduction; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009942607,0.000614761,0.0003687713,0.0002598389,0.000594837,0.0006723285,0.0006575418,0.0004831803,0.001573654],"category_scores_gemma":[0.0002204936,0.0002599591,0.0003271405,0.0002961665,0.0005364423,0.0005163198,0.0002480006,0.0007870913,0.0005820129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001223079,"about_ca_system_score_gemma":0.000529397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001996385,"about_ca_topic_score_gemma":0.001190969,"domain_scores_codex":[0.9999596,0.000008340941,0.00000243712,0.00001360054,0.000006435657,0.000009596685],"domain_scores_gemma":[0.9999325,0.00001093174,0.00002299171,0.000007004349,0.000006842459,0.0000197152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002886122,0.0002998494,0.002121298,0.0005176821,0.0001241117,0.002717349,0.0004234993,0.02669744,0.820169,0.1049442,0.009472122,0.02962736],"study_design_scores_gemma":[0.000441439,0.002226998,0.01735291,0.0001801743,0.0003129862,0.004004606,0.0006718168,0.0720369,0.6918182,0.07607558,0.1346394,0.0002390607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.911328,0.0266425,0.01961401,0.006643799,0.0006184158,0.0001104768,0.002017061,0.0004931104,0.03253273],"genre_scores_gemma":[0.9867662,0.003553747,0.003948813,0.0006560093,0.0001177666,0.00004597605,0.001346328,0.00003033347,0.003534832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996385,"threshold_uncertainty_score":0.008874059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190174211634484,"score_gpt":0.2646194959987981,"score_spread":0.2527177538824533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}