{"id":"W2101904315","doi":"10.1002/path.4205","title":"In Brief: <i>BRCA1</i> and <i>BRCA2</i>","year":2013,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University","funders":"","keywords":"Breast cancer; BRCA2 Protein; Genetics; Identification (biology); Gene; Biology; Genealogy; Medicine; Cancer; Cancer research; Mutation; History; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000824515,0.0002174889,0.0007153933,0.0001133401,0.0000346766,0.00001328062,0.0004249669,0.000344971,0.00002919365],"category_scores_gemma":[0.00009155741,0.0001357445,0.0001642578,0.0001173378,0.0002095238,0.000004692173,0.0001673473,0.0004473283,0.00001352174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000052796,"about_ca_system_score_gemma":0.000365369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004231694,"about_ca_topic_score_gemma":0.00001167527,"domain_scores_codex":[0.9984973,0.0004111009,0.0006305545,0.0001688553,0.0000957209,0.000196485],"domain_scores_gemma":[0.9988212,0.00006853491,0.000624201,0.0003441504,0.00009208724,0.00004980223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000412307,0.00007290429,0.00002202531,0.001473222,0.0002947529,0.0002583864,0.0002947006,0.00001252099,0.003412873,0.00009272838,0.050047,0.9439777],"study_design_scores_gemma":[0.0002570319,0.0001900465,0.000009320174,0.0003715241,0.0002322595,0.008658747,0.00002702254,3.211161e-7,0.0001403732,0.0001675211,0.9898092,0.0001366178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001343857,0.9973586,0.0000892777,0.0001995918,0.0004989849,0.0002161728,0.000009525566,0.000001209625,0.000282753],"genre_scores_gemma":[0.0001832481,0.997935,0.0004511707,0.000477558,0.0005617791,0.0000148823,0.000007496437,0.00003412814,0.0003347427],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.943841,"threshold_uncertainty_score":0.5535501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528290245354431,"score_gpt":0.3221240821997937,"score_spread":0.2968411797462494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}