{"id":"W2101906343","doi":"10.2144/000112266","title":"Whole Genome Amplification of Sodium Bisulfite-Treated DNA Allows the Accurate Estimate of Methylated Cytosine Density in Limited DNA Resources","year":2006,"lang":"en","type":"article","venue":"BioTechniques","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Stanley Foundation; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Sodium bisulfite; Bisulfite; DNA methylation; Methylated DNA immunoprecipitation; Bisulfite sequencing; DNA; Molecular biology; Primer (cosmetics); genomic DNA; Illumina Methylation Assay; Biology; Methylation; Chemistry; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000483766,0.0001650447,0.0002219735,0.0001353488,0.00004924963,0.00001734603,0.0002203341,0.0002908683,0.000003195261],"category_scores_gemma":[0.00008299154,0.0001306663,0.00007920613,0.0003328683,0.0001423842,0.000005733194,0.00008414167,0.00008878715,0.000001109921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001719769,"about_ca_system_score_gemma":0.00002714346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006452461,"about_ca_topic_score_gemma":0.0001982078,"domain_scores_codex":[0.9987659,0.0001496933,0.0004873507,0.0002836834,0.0001370011,0.0001763327],"domain_scores_gemma":[0.9989484,0.00003090964,0.0003360821,0.0004595768,0.0001985009,0.00002652492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008986134,0.00008641552,0.003617931,0.00002001816,0.0000168248,6.923703e-7,0.0000375172,0.0001215088,0.9955082,0.00004716303,0.00003190087,0.0004219523],"study_design_scores_gemma":[0.0001938804,0.0001617448,0.09796994,0.00002158888,0.00002051593,6.503427e-7,0.00001037084,0.0002407172,0.8982583,0.0003802525,0.002616784,0.0001252618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934829,0.001165879,0.004493035,0.0001815779,0.00001614711,0.0003641162,0.00005567745,0.00003726343,0.0002033748],"genre_scores_gemma":[0.9962428,0.0003274121,0.002809237,0.00001762542,0.00003983055,0.00001893527,0.0004500615,0.00002118567,0.0000728859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09724993,"threshold_uncertainty_score":0.5328418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129409217788598,"score_gpt":0.265672923215465,"score_spread":0.2527320014366052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}