{"id":"W2101945735","doi":"10.1002/emmm.200900004","title":"Oxygen‐independent degradation of HIF‐α via bioengineered VHL tumour suppressor complex","year":2009,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Metropolitan University; University Health Network; University of Toronto","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Cancer research; Angiogenesis; HIF1A; Protein subunit; Radioresistance; Hypoxia (environmental); G alpha subunit; Radiation therapy; Biology; Chemistry; Cell biology; Medicine; Biochemistry; Oxygen; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216986,0.0002475787,0.0003791951,0.0001172071,0.00004374247,0.000006768645,0.0002646767,0.0001523823,0.0001710174],"category_scores_gemma":[0.0001097052,0.0002219972,0.0001301654,0.0001911077,0.0001003468,0.000004867441,0.0000463247,0.0001180821,0.00000639846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001364688,"about_ca_system_score_gemma":0.0000572569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006245148,"about_ca_topic_score_gemma":0.00001356061,"domain_scores_codex":[0.9984407,0.00006802769,0.0004022643,0.0003931486,0.0003842255,0.0003116462],"domain_scores_gemma":[0.9990195,0.00000731853,0.0001529328,0.0004902468,0.0001627834,0.0001671942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007762995,0.00007435343,0.00001745838,0.00002287904,0.00006091068,0.000006967896,0.0000466253,0.000062288,0.9851429,0.0003337145,0.009641514,0.004512683],"study_design_scores_gemma":[0.002408934,0.0006844371,0.01518514,0.00004518638,0.0001281686,0.00006291177,0.00006129769,0.0002717419,0.9309124,0.0002981304,0.04963653,0.0003051256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8929764,0.01694039,0.08134878,0.002974756,0.0015137,0.000652833,0.00005087325,0.00005249985,0.003489742],"genre_scores_gemma":[0.994917,0.0004177887,0.001464238,0.001081971,0.001021683,0.00001016411,0.0005786815,0.00002922154,0.0004792666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1019406,"threshold_uncertainty_score":0.9052784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211414775911533,"score_gpt":0.2553690729617343,"score_spread":0.2432549252026189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}