{"id":"W2101945735","doi":"10.1002/emmm.200900004","title":"Oxygen‐independent degradation of HIF‐α via bioengineered VHL tumour suppressor complex","year":2009,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Metropolitan University; University Health Network; University of Toronto","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Cancer research; Angiogenesis; HIF1A; Protein subunit; Radioresistance; Hypoxia (environmental); G alpha subunit; Radiation therapy; Biology; Chemistry; Cell biology; Medicine; Biochemistry; Oxygen; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464549,0.0001849774,0.0001164783,0.000129347,0.00007834646,0.0003001092,0.0001422387,0.0001826703,0.0003845352],"category_scores_gemma":[0.0001295834,0.0000891461,0.0001273934,0.00008289168,0.0002675132,0.0001614026,0.0001257051,0.0003069452,0.0001468217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283382,"about_ca_system_score_gemma":0.0002262043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004581535,"about_ca_topic_score_gemma":0.0006129217,"domain_scores_codex":[0.9999168,0.00001062774,0.000006116049,0.00001882226,0.00003060338,0.0000170158],"domain_scores_gemma":[0.9999102,0.00001744271,0.0000388027,0.00001124823,0.000006644186,0.00001550212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001774811,0.00001240413,0.0000421768,0.00000938941,0.000001720407,0.000017976,0.000007836942,0.0001536798,0.999116,0.000153406,0.00001524131,0.0004524252],"study_design_scores_gemma":[0.000004748538,0.00003899302,0.00017689,6.682295e-7,0.000002277126,0.00004561108,0.000002660776,0.0007133113,0.9982406,0.00001669784,0.0007562175,0.000001314874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872758,0.0005467439,0.01113482,0.00009422509,0.00002322451,0.00002056063,0.00009895812,0.00009419077,0.0007115601],"genre_scores_gemma":[0.9925157,0.0002711161,0.005429038,0.00002488467,0.000005884973,0.00001204384,0.0001981926,0.0000207252,0.001522282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004581535,"threshold_uncertainty_score":0.003107786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211414775911533,"score_gpt":0.2553690729617343,"score_spread":0.2432549252026189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}