{"id":"W2101973145","doi":"10.1158/0008-5472.can-04-3037","title":"Peroxisome Proliferator-Activated Receptor γ Inhibition Prevents Adhesion to the Extracellular Matrix and Induces Anoikis in Hepatocellular Carcinoma Cells","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; McMaster University","keywords":"Anoikis; Peroxisome proliferator-activated receptor; Cancer research; Troglitazone; Cell biology; Cell adhesion; Extracellular matrix; Apoptosis; Programmed cell death; Focal adhesion; Chemistry; Biology; Signal transduction; Receptor; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159367,0.0002869838,0.0002509082,0.0003176072,0.0001545165,0.0001934347,0.0001648938,0.0001582105,0.0009372413],"category_scores_gemma":[0.00009314203,0.0001477581,0.0002628045,0.000216464,0.0001677175,0.00009028246,0.0001314718,0.0004823775,0.0003947105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675649,"about_ca_system_score_gemma":0.0003742024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175456,"about_ca_topic_score_gemma":0.00184535,"domain_scores_codex":[0.9998879,0.00002001241,0.00001095179,0.00001205132,0.00003693877,0.00003211788],"domain_scores_gemma":[0.9999425,0.00001285102,0.00001258323,0.000008622324,0.000007327307,0.00001612079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002347863,0.00008610986,0.0001395168,0.00004062947,0.00001325243,0.00006635993,0.00001174508,0.00008245296,0.9974147,0.00007262195,0.00009325438,0.001744562],"study_design_scores_gemma":[0.00004876652,0.0005556934,0.004317583,0.000004321309,0.0000200256,0.0001733349,0.00002459529,0.0005502165,0.9929387,0.00003052636,0.001332599,0.000003740038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933363,0.001934781,0.001923317,0.0001067195,0.00004619539,0.00003848639,0.0001839799,0.00009105598,0.002339175],"genre_scores_gemma":[0.9915466,0.00216071,0.00134328,0.00007938856,0.0000145699,0.00006293882,0.000678393,0.0000156462,0.004098554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175456,"threshold_uncertainty_score":0.003135443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03272274786993503,"score_gpt":0.3284587805990044,"score_spread":0.2957360327290694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}