{"id":"W2101980933","doi":"10.1373/clinchem.2006.078139","title":"Estimation of Warfarin Maintenance Dose Based on VKORC1 (−1639 G>A) and CYP2C9 Genotypes","year":2007,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Luminex (Canada)","funders":"National Institute on Alcohol Abuse and Alcoholism","keywords":"VKORC1; Warfarin; CYP2C9; Maintenance dose; Genotype; Vitamin K epoxide reductase; Internal medicine; Allele; Biology; Medicine; Endocrinology; Gastroenterology; Pharmacology; Genetics; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002137992,0.0002125771,0.000368449,0.00003457505,0.00009210462,0.000009091814,0.0002335866,0.0004690213,0.0006433022],"category_scores_gemma":[0.0007193832,0.0001987707,0.0001388806,0.0001326892,0.0004383555,0.00002944422,0.00007983318,0.0007762794,0.00004822145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002200535,"about_ca_system_score_gemma":0.00007988593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000214282,"about_ca_topic_score_gemma":0.000001236566,"domain_scores_codex":[0.9981768,0.0001207949,0.0007535115,0.0003933035,0.000179035,0.0003765122],"domain_scores_gemma":[0.9977298,0.001249266,0.0002689466,0.0002907584,0.00009639716,0.0003647687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003897634,0.002503511,0.07536317,0.0005943321,0.0002507982,0.00008462681,0.0001747384,0.008330802,0.3660833,0.0005448509,0.007628814,0.5345435],"study_design_scores_gemma":[0.006823612,0.0001370851,0.02864837,0.00007652498,0.0003430501,0.00001589316,0.00002329816,0.06308026,0.693714,0.001100653,0.2054428,0.0005944758],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847264,0.0006333894,0.001285773,0.000471263,0.0005746014,0.0001677662,0.00005427982,0.00004823086,0.01203828],"genre_scores_gemma":[0.9941531,0.0003515314,0.002012521,0.002087524,0.0003714975,0.000007876129,0.00003742834,0.00002224487,0.0009562804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.533949,"threshold_uncertainty_score":0.8105634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1654067459710714,"score_gpt":0.50496501357986,"score_spread":0.3395582676087886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}