{"id":"W2101983500","doi":"10.1111/j.1365-2958.2010.07465.x","title":"A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair","year":2010,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Harvard University","keywords":"CRISPR; Biology; Nuclease; Genetics; DNA; RecBCD; Plasmid; Palindrome; Cas9; Mutagenesis; Holliday junction; Trans-activating crRNA; DNA repair; Genome; Computational biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458976,0.000473585,0.0005701953,0.000380652,0.0002648018,0.0008848116,0.0004108413,0.000784025,0.001597594],"category_scores_gemma":[0.0002375702,0.0002243676,0.0003555454,0.0002160619,0.000608943,0.0004854787,0.0007167687,0.000812434,0.0009163871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005250198,"about_ca_system_score_gemma":0.0003326195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002338574,"about_ca_topic_score_gemma":0.0002569714,"domain_scores_codex":[0.999674,0.00004278919,0.00001823568,0.000115138,0.00009970383,0.00005011755],"domain_scores_gemma":[0.9998322,0.00002324492,0.00004465968,0.00002640002,0.00002029973,0.00005324667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008882958,0.00001662123,0.0002981197,0.00006595874,0.00001051779,0.0001028358,0.00001116285,0.000140431,0.9906824,0.001132109,0.00008630679,0.007364692],"study_design_scores_gemma":[0.00004284278,0.0003342762,0.003671964,0.00002169465,0.0000303517,0.003223763,0.00002766953,0.003917096,0.9755805,0.001080025,0.01204586,0.00002402331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8715581,0.01309248,0.1057586,0.000772633,0.0001606141,0.00009619604,0.00034961,0.0009594815,0.007252358],"genre_scores_gemma":[0.9614745,0.001405511,0.03168191,0.0001416295,0.00002944903,0.00003439429,0.0002472537,0.00002743224,0.004957952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597594,"threshold_uncertainty_score":0.00534445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002907327633087618,"score_gpt":0.22431264777406,"score_spread":0.2214053201409724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}