{"id":"W2101983500","doi":"10.1111/j.1365-2958.2010.07465.x","title":"A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair","year":2010,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Harvard University","keywords":"CRISPR; Biology; Nuclease; Genetics; DNA; RecBCD; Plasmid; Palindrome; Cas9; Mutagenesis; Holliday junction; Trans-activating crRNA; DNA repair; Genome; Computational biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852416,0.0001219491,0.0001497626,0.0000391497,0.00003609243,0.000005549329,0.0001050763,0.000220001,0.000006738709],"category_scores_gemma":[0.00004733924,0.0001005318,0.00008490581,0.00006955406,0.0001197449,0.000001497282,0.0001734672,0.0001637448,0.000001594408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006266725,"about_ca_system_score_gemma":0.00002811938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005622983,"about_ca_topic_score_gemma":0.0001836126,"domain_scores_codex":[0.9992847,0.00009643104,0.0001966304,0.0002255641,0.00002388183,0.0001727267],"domain_scores_gemma":[0.9995158,0.000008054417,0.00005532023,0.0003630086,0.00003383033,0.00002392942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005778938,0.00002114305,0.001608031,0.00002921523,0.00002979793,0.000003676081,0.00003414561,0.00001344998,0.9978247,0.0001173029,0.00006349339,0.0001972447],"study_design_scores_gemma":[0.0004547693,0.00009859988,0.01966505,0.00001162666,0.00001880399,0.0001267468,0.00004197655,0.00001515682,0.9731579,0.000005764705,0.006295012,0.0001085964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997596,0.0003558934,0.001088935,0.00002181969,0.0006124943,0.0001564003,0.00002158398,0.00001249737,0.0001344209],"genre_scores_gemma":[0.9995848,0.00001031084,0.0002174823,0.000042909,0.00006286688,0.000007969863,0.00003961964,0.00001382572,0.00002020463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02466681,"threshold_uncertainty_score":0.4099568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002907327633087618,"score_gpt":0.22431264777406,"score_spread":0.2214053201409724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}