{"id":"W2101992359","doi":"10.1186/1471-2202-14-47","title":"RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation","year":2013,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Knowledge Development Fund; Universities Space Research Association; National Alliance for Research on Schizophrenia and Depression","keywords":"Downregulation and upregulation; Receptor; Nicotinic agonist; Nicotine; Cell biology; Chemistry; Ganglion type nicotinic receptor; Acetylcholine receptor; Alpha-4 beta-2 nicotinic receptor; Biology; Biochemistry; Nicotinic acetylcholine receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031008,0.0002774759,0.000308286,0.0001201811,0.0001511055,0.0003695702,0.0002558781,0.0002698051,0.001042385],"category_scores_gemma":[0.0001731541,0.00009756057,0.000431513,0.0001555143,0.0002419674,0.0001872151,0.0001994602,0.000645025,0.000450395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004758398,"about_ca_system_score_gemma":0.0002379105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006770003,"about_ca_topic_score_gemma":0.001004927,"domain_scores_codex":[0.9997728,0.00003190562,0.00002455541,0.00004178485,0.00006071438,0.00006823763],"domain_scores_gemma":[0.9998671,0.00001935482,0.00004073792,0.00001776486,0.00002717136,0.00002784703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007602352,0.0000160069,0.0001119452,0.00002714818,0.000004094918,0.00002009913,0.00001004087,0.00002711348,0.9993038,0.00003187673,0.00002332697,0.0003485192],"study_design_scores_gemma":[0.00000878463,0.000124454,0.003347145,0.0000050041,0.00001650096,0.0001050999,0.00002683105,0.0004867817,0.9944146,0.00001299734,0.001448945,0.000002826063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948156,0.001134605,0.002120676,0.0001162607,0.00002694359,0.0000357171,0.0003745127,0.00007404256,0.001301608],"genre_scores_gemma":[0.9923725,0.0008202648,0.00311725,0.0001111224,0.00001071979,0.00005830196,0.001008394,0.00005192204,0.00244953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042385,"threshold_uncertainty_score":0.00348717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694033432392876,"score_gpt":0.2549589673325696,"score_spread":0.2380186330086408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}