{"id":"W2102001309","doi":"10.1093/hmg/ddt594","title":"The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Unfolded protein response; Endoplasmic reticulum; Cell biology; Transmembrane protein; Amyotrophic lateral sclerosis; Mutant; Mutant protein; Mutation; Point mutation; Genetics; Pathology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005704596,0.0003609397,0.0004792351,0.00007821069,0.0005769643,0.0002721878,0.0004653049,0.000246629,0.000403355],"category_scores_gemma":[0.0002088775,0.000253051,0.0003387361,0.0001917053,0.0003935531,0.00007676023,0.0001536411,0.0003752873,0.0002136933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490241,"about_ca_system_score_gemma":0.0001247884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002068031,"about_ca_topic_score_gemma":0.00001051721,"domain_scores_codex":[0.9964615,0.0003181175,0.0007253085,0.0006153287,0.0009099835,0.0009697509],"domain_scores_gemma":[0.9974507,0.00005840803,0.0001990125,0.001199411,0.0007270479,0.0003654384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001731975,0.000112743,0.0005748818,0.0001116634,0.0001842394,0.000009339224,0.0001060508,0.000007613954,0.9938068,0.001075048,0.001333849,0.002504623],"study_design_scores_gemma":[0.01729103,0.00398173,0.6223094,0.0007405312,0.000324348,0.00002418713,0.00006963822,0.003493271,0.3105909,0.03003943,0.009651802,0.001483712],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819677,0.0007044287,0.002065978,0.006742023,0.00005212217,0.008018859,0.00002562572,0.00008890113,0.0003344034],"genre_scores_gemma":[0.9895879,0.00003437447,0.002395843,0.001433213,0.0002258619,0.002788105,0.00002773914,0.000114455,0.003392508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6832159,"threshold_uncertainty_score":0.9999922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05922276795304543,"score_gpt":0.3266127702739466,"score_spread":0.2673900023209012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}