{"id":"W2102016263","doi":"10.1182/blood.v97.1.107","title":"Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Viral vector; Vector (molecular biology); Toxicity; Factor IX; Medicine; Antibody; Coagulation; Immunology; In vivo; Internal medicine; Pharmacology; Biology; Recombinant DNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002745918,0.0001816118,0.0002256093,0.0001871714,0.00005013617,0.00001773333,0.0001653394,0.0001649386,0.00001015457],"category_scores_gemma":[0.0000583234,0.0001860926,0.00003120673,0.0002528729,0.00006037449,0.00001491466,0.00008943446,0.0001512429,0.000002415313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006267168,"about_ca_system_score_gemma":0.0002036339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306058,"about_ca_topic_score_gemma":0.008502907,"domain_scores_codex":[0.9985397,0.0001284629,0.0004079183,0.0004353145,0.0001745387,0.0003140756],"domain_scores_gemma":[0.9995004,0.00002046712,0.00005913034,0.0002475782,0.00007515626,0.00009726541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001795496,0.0002803702,0.08338724,0.00004261701,0.00003170597,0.00004741346,0.0005730137,0.00002076523,0.9091851,4.331508e-7,0.000009784522,0.004626022],"study_design_scores_gemma":[0.002838797,0.001000173,0.09774686,0.000113737,0.00000881918,0.00007722604,0.00009080816,0.00008757418,0.8977823,9.239553e-7,0.0000316268,0.0002211329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983157,0.001176441,0.000007397007,0.000008433511,0.00009629707,0.0003073554,0.00002932127,0.00001135676,0.00004770246],"genre_scores_gemma":[0.9992908,0.0002896477,0.0000758213,0.0000193292,0.0001294533,0.00002542731,0.00006443269,0.00002295769,0.0000821888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01435961,"threshold_uncertainty_score":0.7588636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025398770693103,"score_gpt":0.2641029640979544,"score_spread":0.2438489763910234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}