{"id":"W2102016263","doi":"10.1182/blood.v97.1.107","title":"Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Viral vector; Vector (molecular biology); Toxicity; Factor IX; Medicine; Antibody; Coagulation; Immunology; In vivo; Internal medicine; Pharmacology; Biology; Recombinant DNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002153332,0.0002474859,0.0003004241,0.0002097867,0.000132051,0.0002841839,0.0001357162,0.000314162,0.0005670087],"category_scores_gemma":[0.0002808167,0.0001359933,0.0001586026,0.00009720018,0.000392368,0.0002845774,0.0001089032,0.0005247749,0.0001655595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003276065,"about_ca_system_score_gemma":0.0001326745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004693947,"about_ca_topic_score_gemma":0.0005933136,"domain_scores_codex":[0.9997628,0.00005043036,0.00002692252,0.00005703346,0.00005519961,0.00004757723],"domain_scores_gemma":[0.9998288,0.00004409766,0.00005834084,0.00002127126,0.00001278225,0.00003479919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002248613,0.0001220942,0.0004994248,0.00002661131,0.000006711614,0.0001372668,0.00003232898,0.0001177574,0.9961523,0.0001205691,0.00007409979,0.00248574],"study_design_scores_gemma":[0.00008287336,0.005953514,0.006150693,0.00000653704,0.00004331663,0.002091947,0.00005102925,0.00205716,0.9818602,0.00008814499,0.001605149,0.000009410052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976444,0.0002751785,0.001528952,0.00004066624,0.000007087419,0.00001443914,0.00005353706,0.00004682629,0.0003889299],"genre_scores_gemma":[0.9970811,0.0002534591,0.001222277,0.00002400855,0.00000491519,0.00002067922,0.0001842573,0.00001629084,0.001193107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005670087,"threshold_uncertainty_score":0.002376914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025398770693103,"score_gpt":0.2641029640979544,"score_spread":0.2438489763910234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}