{"id":"W2102023695","doi":"10.1002/anie.201105138","title":"The Use of Fluoride as a Leaving Group: S<sub>N</sub>2′ Displacement of a CF Bond on 3,3‐Difluoropropenes with Organolithium Reagents To Give Direct Access to Monofluoroalkenes","year":2011,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Fluoride; Leaving group; Reagent; Chemistry; Nucleophile; Lithium fluoride; Nucleophilic substitution; Combinatorial chemistry; Substitution reaction; Group (periodic table); Fluorine; Lithium (medication); Medicinal chemistry; Inorganic chemistry; Organic chemistry; Catalysis; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320381,0.0003623964,0.0001525634,0.0001416489,0.0002497223,0.0002026028,0.0004938719,0.0004075364,0.001913648],"category_scores_gemma":[0.0002527211,0.000156425,0.0002111108,0.0001109415,0.0004051416,0.0006064528,0.0002889867,0.0004897957,0.0005986468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798511,"about_ca_system_score_gemma":0.0003239608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058969,"about_ca_topic_score_gemma":0.001739547,"domain_scores_codex":[0.9998865,0.00001523731,0.000008618634,0.00003133914,0.00002141351,0.00003687424],"domain_scores_gemma":[0.9999228,0.00001961696,0.00002094347,0.00001738338,0.000009582029,0.000009693268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001900022,0.00002691901,0.0002068643,0.0001662032,0.00001259343,0.0002446377,0.0001137748,0.0001819099,0.9779226,0.004408417,0.0005312776,0.0159948],"study_design_scores_gemma":[0.000008027509,0.0001507651,0.0002234808,0.000006688073,0.000005477387,0.0003011335,0.00001719266,0.0001543627,0.9920185,0.0001821371,0.006922453,0.000009827259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8888927,0.005408859,0.07018616,0.0009290942,0.0003523096,0.0001509308,0.0006412492,0.0006647723,0.03277403],"genre_scores_gemma":[0.9811502,0.001978663,0.01167687,0.0001080853,0.00002719,0.00004293347,0.0001813679,0.0000522111,0.00478261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001913648,"threshold_uncertainty_score":0.006401777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129650678928385,"score_gpt":0.3712429769811414,"score_spread":0.2415922980527564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}