{"id":"W2102025275","doi":"10.1046/j.1365-2893.2003.00397.x","title":"Targeted destruction of the polymerized human serum albumin binding site within the preS2 region of the HBV surface antigen while retaining full immunogenicity for this epitope","year":2003,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Provincial Health Services Authority","keywords":"Epitope; Immunogenicity; Virology; Antigen; Hepatitis B virus; Antibody; Epitope mapping; Conformational epitope; Chemistry; Biology; Virus; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065123,0.000320437,0.000147855,0.00008377175,0.00007817795,0.0001778967,0.0001032779,0.0002240858,0.0006921643],"category_scores_gemma":[0.00006473471,0.0000955638,0.0002538104,0.0000697924,0.0001327262,0.0001181828,0.0001373594,0.0002249588,0.0002216456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001239713,"about_ca_system_score_gemma":0.00014113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002081977,"about_ca_topic_score_gemma":0.0002553393,"domain_scores_codex":[0.9999444,0.000008659108,0.000004499094,0.00001364276,0.00001219474,0.00001656965],"domain_scores_gemma":[0.99994,0.00000748463,0.00002689818,0.000006113503,0.000005697086,0.00001364484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000503578,0.00001630592,0.00005686767,0.00001290049,0.000002792552,0.00002966009,0.000003801911,0.00004696568,0.9991598,0.00003562831,0.000005408318,0.0005795641],"study_design_scores_gemma":[0.00001317311,0.000623018,0.001351451,0.0000020557,0.00001141809,0.0001745674,0.000005827448,0.0006566442,0.9961417,0.00001593667,0.001000906,0.000003260091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967918,0.0002564595,0.002454085,0.00002215666,0.00001317077,0.00002048859,0.00003443174,0.00002724084,0.0003803001],"genre_scores_gemma":[0.9953116,0.0001752862,0.003213277,0.00003025522,0.000006302565,0.00001326292,0.00006571596,0.000008958912,0.00117532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006921643,"threshold_uncertainty_score":0.002315521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02572164724437611,"score_gpt":0.2674497009545463,"score_spread":0.2417280537101702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}