{"id":"W2102043258","doi":"10.1158/1541-7786.mcr-12-0575","title":"TDP1 and PARP1 Deficiency Are Cytotoxic to Rhabdomyosarcoma Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Rhabdomyosarcoma; PARP1; Cancer research; Gene knockdown; Topoisomerase; Poly ADP ribose polymerase; Biology; PARP inhibitor; Cytotoxic T cell; Irinotecan; Olaparib; Embryonal rhabdomyosarcoma; Molecular biology; Cell culture; Sarcoma; Polymerase; Medicine; Cancer; DNA; In vitro; Pathology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003426953,0.000174319,0.0001571833,0.0001295675,0.0001689206,0.0001219704,0.0003313166,0.0001305389,0.0001805615],"category_scores_gemma":[0.00002806084,0.0001681236,0.00006477095,0.000287235,0.0001128637,0.000004950176,0.0003655075,0.000200426,0.0001153862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005323717,"about_ca_system_score_gemma":0.0001408457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005911721,"about_ca_topic_score_gemma":0.0001061674,"domain_scores_codex":[0.9980456,0.000121605,0.0001613483,0.000585463,0.000429628,0.0006563837],"domain_scores_gemma":[0.9988557,0.00001153737,0.00003493868,0.0005148219,0.0002781895,0.0003048639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003587854,0.00003973061,0.0001709597,0.00002655266,0.00002332015,0.0000110933,0.00005498335,0.00003105832,0.9870514,0.0002340088,0.00250386,0.009817113],"study_design_scores_gemma":[0.0003558212,0.0003560939,0.0006849232,0.00002676637,0.00000662191,0.000006501361,0.0001288448,0.00004109234,0.9458964,0.0005396174,0.0517318,0.0002255536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901799,0.004133668,0.002566463,0.001409716,0.0001236259,0.0007923407,0.00002683971,0.00001348671,0.0007539722],"genre_scores_gemma":[0.9952846,0.0007197612,0.0005666731,0.001315398,0.0001196946,0.00062561,0.000008091776,0.00004804696,0.001312115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04922794,"threshold_uncertainty_score":0.6855883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417663004471364,"score_gpt":0.344866277531008,"score_spread":0.3106896474862944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}