{"id":"W2102043258","doi":"10.1158/1541-7786.mcr-12-0575","title":"TDP1 and PARP1 Deficiency Are Cytotoxic to Rhabdomyosarcoma Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Rhabdomyosarcoma; PARP1; Cancer research; Gene knockdown; Topoisomerase; Poly ADP ribose polymerase; Biology; PARP inhibitor; Cytotoxic T cell; Irinotecan; Olaparib; Embryonal rhabdomyosarcoma; Molecular biology; Cell culture; Sarcoma; Polymerase; Medicine; Cancer; DNA; In vitro; Pathology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891843,0.0004208022,0.0002926021,0.0001379754,0.0001782088,0.0003707627,0.0002736901,0.0003341999,0.002698701],"category_scores_gemma":[0.000150368,0.0001258022,0.0002570942,0.0001734818,0.0002182523,0.0001889042,0.0002019938,0.0005830736,0.0009162085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003101368,"about_ca_system_score_gemma":0.0002438356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003538681,"about_ca_topic_score_gemma":0.0003724708,"domain_scores_codex":[0.9997301,0.00004194152,0.00004108623,0.00006934945,0.00007138556,0.00004610317],"domain_scores_gemma":[0.999818,0.00004994874,0.0000448305,0.00003193069,0.0000272279,0.00002816928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003917007,0.00006495669,0.0005614303,0.0001590199,0.00001928558,0.0001323727,0.00002441243,0.0002381777,0.9952436,0.00007662042,0.0002343161,0.002853945],"study_design_scores_gemma":[0.0000258804,0.0005106111,0.006697604,0.0000113479,0.00002193728,0.0006419442,0.00003461192,0.000477581,0.987359,0.00002638435,0.004188902,0.000004259319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825815,0.007504313,0.003610302,0.0002740893,0.0001411696,0.00007414211,0.002022352,0.0002315922,0.003560522],"genre_scores_gemma":[0.9913224,0.001744375,0.001618186,0.00008005121,0.00001453814,0.00008504478,0.002385003,0.00001945706,0.002730846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698701,"threshold_uncertainty_score":0.009028018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417663004471364,"score_gpt":0.344866277531008,"score_spread":0.3106896474862944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}