{"id":"W2102043340","doi":"10.1124/dmd.112.049098","title":"Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University","keywords":"Drug metabolism; Metabolism; CYP3A4; Bioartificial liver device; Hepatocyte; Liver cytology; Cell culture; Chemistry; Hepatic stellate cell; Toxicity; Hydroxylation; In vitro; Biochemistry; Pharmacology; Cytochrome P450; Biology; Liver metabolism; Endocrinology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005659624,0.0001493486,0.0004930044,0.0002698975,0.00003846816,0.00000419151,0.00003110637,0.00009283127,0.00001146635],"category_scores_gemma":[0.00004596102,0.0001286464,0.00003666719,0.0002319248,0.0003341221,0.0003437106,0.00003929015,0.0001487466,0.000001286394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006133807,"about_ca_system_score_gemma":0.00002184032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003457365,"about_ca_topic_score_gemma":0.00004185356,"domain_scores_codex":[0.9988421,0.0002211597,0.0003467862,0.0002726328,0.00009999011,0.0002173947],"domain_scores_gemma":[0.9995024,0.00005989671,0.0001407269,0.0001495127,0.00004984144,0.00009758816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001293999,0.001543947,0.006100337,0.0001854159,0.00001915567,0.00001125649,0.007111069,7.108945e-7,0.9758558,0.0008365283,0.00004290283,0.00699888],"study_design_scores_gemma":[0.005054871,0.00009760846,0.2293718,0.00007166992,0.000210439,0.0000390489,0.0005185092,0.00008521554,0.7638319,0.0003977116,0.0001833335,0.0001378923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848734,0.01417533,0.00001797881,0.0001011498,0.0003234826,0.0003790393,0.00009456562,0.00000893126,0.00002614648],"genre_scores_gemma":[0.997565,0.00175344,0.0003117895,0.00005714233,0.0001828863,0.00002052001,0.00006922657,0.000009173402,0.00003087484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2232715,"threshold_uncertainty_score":0.5246047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311781045058548,"score_gpt":0.2783538839562321,"score_spread":0.2652360735056466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}