{"id":"W2102043340","doi":"10.1124/dmd.112.049098","title":"Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University","keywords":"Drug metabolism; Metabolism; CYP3A4; Bioartificial liver device; Hepatocyte; Liver cytology; Cell culture; Chemistry; Hepatic stellate cell; Toxicity; Hydroxylation; In vitro; Biochemistry; Pharmacology; Cytochrome P450; Biology; Liver metabolism; Endocrinology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002913973,0.0003191969,0.0004788538,0.0002344964,0.0002064782,0.0003054188,0.0001479336,0.0002043299,0.001013898],"category_scores_gemma":[0.0001938609,0.0001413008,0.0003058874,0.0003523869,0.0003262581,0.0004330969,0.0001636646,0.0003614014,0.0002742781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000401898,"about_ca_system_score_gemma":0.0004825451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002197128,"about_ca_topic_score_gemma":0.002414708,"domain_scores_codex":[0.999754,0.00007014693,0.00003413896,0.00003691168,0.00004751392,0.00005723391],"domain_scores_gemma":[0.999806,0.00006264685,0.00002501644,0.00003933185,0.00003086362,0.0000361456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002026837,0.00009870024,0.0005178145,0.00002864006,0.00000893513,0.00008534579,0.00008105816,0.0002853903,0.9952334,0.0001567792,0.00005673631,0.001420401],"study_design_scores_gemma":[0.00003279401,0.0006065693,0.004926218,0.000002822163,0.00001479548,0.00006815411,0.00004616862,0.001365727,0.9921938,0.00007831072,0.0006553648,0.000009291132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975666,0.0003218311,0.0007076366,0.00005434257,0.00003196823,0.00001578778,0.0004797158,0.00002939,0.0007926597],"genre_scores_gemma":[0.993318,0.0002313157,0.001753492,0.0000499644,0.00001788067,0.00003529429,0.001233728,0.00001755418,0.003342781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197128,"threshold_uncertainty_score":0.004368722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311781045058548,"score_gpt":0.2783538839562321,"score_spread":0.2652360735056466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}