{"id":"W2102071927","doi":"10.1534/genetics.114.161307","title":"Synthetic Cytotoxicity: Digenic Interactions with TEL1/ATM Mutations Reveal Sensitivity to Low Doses of Camptothecin","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Canadian Cancer Society Research Institute; Infrastructure Canada; National Institutes of Health; Cancer Research Institute","keywords":"Biology; Synthetic lethality; DNA damage; Topoisomerase; Camptothecin; Cytotoxic T cell; Genetics; Cytotoxicity; DNA; Gene; Saccharomyces cerevisiae; Mutation; Mutant; Molecular biology; Cell biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630004,0.0005555212,0.0002565352,0.0006149899,0.0002322307,0.0003162107,0.0003142465,0.0003703529,0.002271257],"category_scores_gemma":[0.0002019522,0.0002180289,0.0003223588,0.0003281704,0.0003308996,0.0001470556,0.0004819476,0.0006221119,0.0003240692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005325997,"about_ca_system_score_gemma":0.0002993305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532654,"about_ca_topic_score_gemma":0.003011492,"domain_scores_codex":[0.9995918,0.00006842101,0.00005300878,0.00008028605,0.0001550318,0.00005151338],"domain_scores_gemma":[0.9996601,0.00009462424,0.0001005148,0.00003714012,0.00002124704,0.00008646065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005029952,0.00002154845,0.0002036626,0.00001324592,0.00000546087,0.00004233388,0.000005084706,0.00007214997,0.9990206,0.00005280276,0.00001737399,0.000495471],"study_design_scores_gemma":[0.00001586801,0.0002955716,0.007790956,0.000005445796,0.00002690775,0.0005443564,0.00002873739,0.001297088,0.9885364,0.00004474541,0.001405154,0.000008790465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920026,0.0005090965,0.003727508,0.00008078609,0.00001842761,0.00007553769,0.0009601132,0.0001181148,0.002507782],"genre_scores_gemma":[0.9930489,0.0002671836,0.003124248,0.00006105912,0.000003826622,0.00004819826,0.0009614936,0.00005306098,0.002432052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002271257,"threshold_uncertainty_score":0.007598162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008114805080798499,"score_gpt":0.248888371057129,"score_spread":0.2407735659763305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}