{"id":"W2102071927","doi":"10.1534/genetics.114.161307","title":"Synthetic Cytotoxicity: Digenic Interactions with TEL1/ATM Mutations Reveal Sensitivity to Low Doses of Camptothecin","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Canadian Cancer Society Research Institute; Infrastructure Canada; National Institutes of Health; Cancer Research Institute","keywords":"Biology; Synthetic lethality; DNA damage; Topoisomerase; Camptothecin; Cytotoxic T cell; Genetics; Cytotoxicity; DNA; Gene; Saccharomyces cerevisiae; Mutation; Mutant; Molecular biology; Cell biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433313,0.0001420782,0.0001558905,0.00005306473,0.00007254905,0.00001671022,0.00009365525,0.00006428873,0.00001462868],"category_scores_gemma":[0.00003685058,0.0001306212,0.00006610339,0.0001092069,0.00006018765,0.00000189126,0.00006156414,0.00006355144,0.00000988389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001796935,"about_ca_system_score_gemma":0.00007142182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001923132,"about_ca_topic_score_gemma":0.0006188256,"domain_scores_codex":[0.999149,0.00007231313,0.000174199,0.0002772946,0.0001236641,0.0002035646],"domain_scores_gemma":[0.9992348,0.0000333122,0.00008245157,0.0004240846,0.0001252516,0.0001001223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005243959,0.00006996256,0.0003037044,0.00001679767,0.00005762136,9.413769e-7,0.0001227472,0.002103804,0.9924406,0.00006201179,0.0001048025,0.004664508],"study_design_scores_gemma":[0.0002907097,0.000553787,0.001176991,0.00003044887,0.00005348499,0.00002776141,0.00008380378,0.0002309032,0.9826005,0.0001151292,0.01465138,0.0001850991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9202498,0.0000640871,0.07880009,0.0001425515,0.0001150768,0.0002198285,0.00005767383,0.00001037504,0.0003404676],"genre_scores_gemma":[0.9935867,0.00003385223,0.005406301,0.0004318325,0.0001505805,0.00002396716,0.00002768909,0.00003048005,0.0003085853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07339379,"threshold_uncertainty_score":0.5326577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008114805080798499,"score_gpt":0.248888371057129,"score_spread":0.2407735659763305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}