{"id":"W2102072515","doi":"10.1096/fj.05-4986com","title":"Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Amyloid precursor protein secretase; Amyloid precursor protein; Senile plaques; Transcription (linguistics); BACE1-AS; Inducer; Gene expression; Cell biology; Chemistry; Biology; Molecular biology; Gene; Biochemistry; Internal medicine; Alzheimer's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106381,0.0003600365,0.000367278,0.0003562078,0.0001549481,0.0006444806,0.0002307618,0.0003051883,0.001077951],"category_scores_gemma":[0.0003243199,0.0001924547,0.0002633546,0.0002451008,0.0004102867,0.0002819752,0.000322447,0.0005397556,0.0004284306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004440313,"about_ca_system_score_gemma":0.0002486764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009562748,"about_ca_topic_score_gemma":0.0007144007,"domain_scores_codex":[0.9996599,0.0000395094,0.00003507165,0.0001173922,0.00006956689,0.00007854011],"domain_scores_gemma":[0.9997436,0.00007044493,0.00006167451,0.00003966168,0.00003733595,0.0000473434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005289983,0.00001135589,0.0001256433,0.00001276066,0.000001377565,0.00001416021,0.00001102833,0.00001485566,0.9991559,0.00003499928,0.00000718276,0.0005577439],"study_design_scores_gemma":[0.000005589231,0.0001059149,0.003778501,0.000003266499,0.000008233867,0.00009088086,0.00002087112,0.0003981824,0.9946837,0.00004080962,0.0008593209,0.000004819688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877691,0.003964027,0.005926845,0.0001120989,0.00002978882,0.00004477008,0.000453071,0.0001903018,0.001510013],"genre_scores_gemma":[0.991985,0.001141329,0.002844695,0.00004352713,0.00001348315,0.00006633122,0.0006210723,0.00003731587,0.003247198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077951,"threshold_uncertainty_score":0.003606081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795316045001265,"score_gpt":0.2892143141802254,"score_spread":0.2512611537302127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}