{"id":"W2102094932","doi":"10.1158/1078-0432.ccr-04-2379","title":"Increased Cyclooxygenase-2 Expression in Duodenal Compared with Colonic Tissues in Familial Adenomatous Polyposis and Relationship to the −765G → <i>C COX-2</i> Polymorphism","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Familial adenomatous polyposis; Gastroenterology; Internal medicine; Medicine; Colorectal cancer; Duodenum; Cyclooxygenase; Adenomatous polyposis coli; Intestinal polyp; Adenocarcinoma; COX-2 inhibitor; Duodenal cancer; Immunohistochemistry; Pathology; Cancer; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003236508,0.0001680701,0.0004798642,0.0002917123,0.0001760802,0.00003520774,0.0002104182,0.0001996864,0.00009020315],"category_scores_gemma":[0.001032187,0.0001094519,0.00004973313,0.0006894656,0.000364004,0.00008610127,0.0001379659,0.001237486,0.00007630856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000268654,"about_ca_system_score_gemma":0.0005893051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002422319,"about_ca_topic_score_gemma":0.01042665,"domain_scores_codex":[0.9966176,0.0009703448,0.0006089584,0.0004734085,0.0007495512,0.0005801109],"domain_scores_gemma":[0.9968489,0.002096034,0.00006735988,0.0004165661,0.0001277499,0.0004433438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006161584,0.0002985624,0.9813585,0.0000706936,0.00001728493,0.0002156427,0.0009295672,0.00006957711,0.002109309,0.00003638264,0.005050482,0.003682471],"study_design_scores_gemma":[0.005968453,0.000733548,0.9831367,0.0006705896,0.00001878966,0.00002062409,0.0002041846,0.0006265203,0.002178014,0.00002133192,0.006268296,0.0001529686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873254,0.003104487,0.000004466661,0.007859236,0.00009449369,0.001324203,0.00001460602,0.00002672115,0.0002464367],"genre_scores_gemma":[0.997255,0.0003451013,0.0001883574,0.0008408501,0.0007241689,0.0003779239,0.00001022298,0.00003098681,0.0002273726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009929666,"threshold_uncertainty_score":0.5818313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09705796834636993,"score_gpt":0.4373965849768265,"score_spread":0.3403386166304566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}